Benzene, 1-bromo-2-[(S)-methylsulfinyl]-

Base Information

• Chemical Name: Benzene, 1-bromo-2-[(S)-methylsulfinyl]-
• CAS No.: 146235-11-2
• Molecular Formula: C₇H₇BrOS
• Molecular Weight: 219.102
• Mol file: 146235-11-2.mol

Synonyms:

Chemical Property of Benzene, 1-bromo-2-[(S)-methylsulfinyl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzene, 1-bromo-2-[(S)-methylsulfinyl]-

There total 30 articles about Benzene, 1-bromo-2-[(S)-methylsulfinyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-bromo-1-(methylsulfanyl)benzene (19614-16-5) → (R)-2-bromophenyl methyl sulfoxide (7321-58-6,126218-83-5,146235-11-2)

Guidance literature:

2-bromo-1-(methylsulfanyl)benzene; With manganese(II) triflate; N₁,N₂-bis(2-((R)-4-isopropyl-4,5-dihydrooxazol-2-yl)phenyl)benzene-1,2-diamine; In acetonitrile; at 20 ℃; for 6h; Inert atmosphere; Green chemistry;

With 1-Adamantanecarboxylic acid; dihydrogen peroxide; In isopropyl alcohol; acetonitrile; at -20 ℃; for 2h; enantioselective reaction; Inert atmosphere; Green chemistry;

DOI:10.1039/c4ra09832c

Reference yield: 91.0%

2-bromo-1-(methylsulfanyl)benzene (19614-16-5) → (S)-methyl o-bromophenyl sulfoxide (7321-58-6,126218-83-5,146235-11-2)

Guidance literature:

With tert.-butylhydroperoxide; iron(III) sulfate; (R,R)-N,N'-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediamine; In water; for 2.5h; chemoselective reaction; Reflux;

DOI:10.1002/aoc.1859

Reference yield: 81.0%

3-bromo-1-(methylthio)benzene (33733-73-2) → 1-bromo-2-(methylsulfonyl)benzene (33951-33-6) + (S)-methyl o-bromophenyl sulfoxide (7321-58-6,126218-83-5,146235-11-2)

Guidance literature:

With phosphate buffer; dihydrogen peroxide; chiral Al(salalen); In methanol; at 20 ℃; for 24h;

DOI:10.1002/anie.200700792

upstream raw materials:

N-chloro-4-methylbenzenesulfonamide

2-bromo-1-(methylsulfanyl)benzene

racemic methyl phenyl sulfoxide

o-bromothiophenol

Downstream raw materials:

1,4-dihydronaphthalene-1,4-epoxide

Ethyl methyl sulfoxide

4-Methylbiphenyl

Methyl p-tolyl sulfoxide

Refernces

• 1、 Zhang, Huaiyuan,Cormanich, Rodrigo A.,Wirth, Thomas. "Chiral Ligands in Hypervalent Iodine Compounds: Synthesis and Structures of Binaphthyl-Based λ3-Iodanes". supporting information. . Retrieved 2021/12/22.
• 2、 Liu, Shuyang,Tian, Miao,Bu, Xiubin,Tian, Hua,Yang, Xiaobo. "Covalent Organic Frameworks toward Diverse Photocatalytic Aerobic Oxidations". supporting information. p. 7738 - 7744. Retrieved 2021/05/07.