4-Chlorobenzyl(trimethylsilyl) ether

Base Information

• Chemical Name: 4-Chlorobenzyl(trimethylsilyl) ether
• CAS No.: 14856-74-7
• Molecular Formula: C10H15ClOSi
• Molecular Weight: 214.767
• Hs Code.: 2931900090
• Mol file: 14856-74-7.mol

Synonyms:trimethylsilyl 4-chlorobenzyl ether;4-chlorobenzyl trimethylsilyl ether;p-ClC6H4CH2OTMS;4-Cl-C6H4CH2OTMS;4-Cl-C6H4CH2OSiMe3;4-Cl-Ph-CH2OTMS;

Chemical Property of 4-Chlorobenzyl(trimethylsilyl) ether

Chemical Property:

• Boiling Point: 228 °C
• PSA: 9.23000
• Density: 1.026±0.06 g/cm3(Predicted)
• LogP: 3.69150

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Chlorobenzyl(trimethylsilyl) ether

There total 10 articles about 4-Chlorobenzyl(trimethylsilyl) ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1,1,1,3,3,3-hexamethyl-disilazane (999-97-3) + para-Chlorobenzyl alcohol (873-76-7) → 4-chlorobenzyltrimethylsilyl ether (14856-74-7)

Guidance literature:

With aluminum potassium sulfate dodecahydrate; In acetonitrile; at 20 ℃; for 0.333333h;

Reference yield: 98.0%

1,1,1,2,2,2-hexamethyldisilane (1450-14-2) + para-Chlorobenzyl alcohol (873-76-7) → 4-chlorobenzyltrimethylsilyl ether (14856-74-7)

Guidance literature:

With lanthanum(III) nitrate hexahydrate; In acetonitrile; at 20 ℃;

DOI:10.1080/10426500802509616

Reference yield: 97.0%

sodium (4-chlorophenyl)(hydroxy)methanesulfonate (46175-04-6) + 1,1,1,3,3,3-hexamethyl-disilazane (999-97-3) → 4-chlorobenzyltrimethylsilyl ether (14856-74-7)

Guidance literature:

With sodium tetrahydroborate; montmorillonite K-10; In acetonitrile; at 20 ℃; for 0.133333h;

DOI:10.1080/104265090969009

upstream raw materials:

1,1,1,3,3,3-hexamethyl-disilazane

para-Chlorobenzyl alcohol

chloro-trimethyl-silane

4-chlorobenzaldehyde

Downstream raw materials:

4-chlorobenzyl acetate

1-chloro-4-(iodomethyl)benzene

(4-chlorophenyl)dichloromethane

2-(4-chlorobenzyloxy)tetrahydro-2H-pyran

Refernces

• 1、 Oladee, Razieh,Zareyee, Daryoush,Khalilzadeh, Mohammad A.. "KF/clinoptilolite NPs: An efficient and heterogeneous catalyst for chemoselective silylation of alcohols and phenols". . p. 731 - 737. Retrieved 2021/03/31.
• 2、 Mashhadinezhad, Maryam,Shirini, Farhad,Mamaghani, Manouchehr. "Nanoporous Na+-montmorillonite perchloric acid as an efficient and recyclable catalyst for the chemoselective protection of hydroxyl groups". . p. 2099 - 2107. Retrieved 2019/01/03.