(2-Methylphenyl)carbamic acid methyl ester

Base Information

• Chemical Name: (2-Methylphenyl)carbamic acid methyl ester
• CAS No.: 14983-92-7
• Molecular Formula: C9H11NO2
• Molecular Weight: 165.192
• Hs Code.: 2924299090
• Mol file: 14983-92-7.mol

Synonyms:methyl-N-(2-tolyl)carbamate;Methyl N-(o-tolyl)carbamate;methy o-tolylurethane;methyl o-tolylcarbamate;(2-methylphenyl)-carbamic acid, methyl ester;

Chemical Property of (2-Methylphenyl)carbamic acid methyl ester

Chemical Property:

• Melting Point: 52-53 °C(Solv: dichloromethane (75-09-2); hexane (110-54-3))
• Boiling Point: 202.5±19.0 °C(Predicted)
• PKA: 13.87±0.70(Predicted)
• PSA: 38.33000
• Density: 1.138±0.06 g/cm3(Predicted)
• LogP: 2.24630

Purity/Quality:

METHYL N-(O-TOLYL)CARBAMATE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-Methylphenyl)carbamic acid methyl ester

There total 21 articles about (2-Methylphenyl)carbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + o-Methylbenzamid (527-85-5) → methyl N-(2-methylphenyl)carbamate (14983-92-7)

Guidance literature:

With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; silver(I) acetate; In N,N-dimethyl-formamide; for 12h; Ambient temperature; or Hg(OAc)2, NBS-Hg(OAc)2;

DOI:10.1016/0040-4039(90)80016-F

Reference yield: 97.0%

methyl chloroformate (79-22-1) + o-toluidine (95-53-4) → methyl N-(2-methylphenyl)carbamate (14983-92-7)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.joc.1c01379

Reference yield: 92.0%

methanol (67-56-1) + formyl radical (2597-44-6) + 1-methyl-2-nitrobenzene (88-72-2) → methyl N-(2-methylphenyl)carbamate (14983-92-7)

Guidance literature:

With tetradecyl(trihexyl)phosphonium bistriflamide; 1,10-Phenanthroline; palladium dichloride; at 135 ℃; for 24h; under 25858.1 Torr;

DOI:10.1021/ol802096x

upstream raw materials:

methyl chloroformate

o-toluidine

methanol

carbon monoxide

Downstream raw materials:

Chloromethyl-o-tolyl-carbamic acid methyl ester

N,2-dimethylaniline

methyl N-[2-(chloromethyl)phenyl]carbamate

2-methyl-N-methylaniline hydrochloride

Refernces

• 1、 Yadav,Subba Reddy,Kiran Kumar Reddy. "Indium-mediated efficient conversion of azides to carbamates". . p. 571 - 573. Retrieved 2000.
• 2、 -. "Method for synthesizing P-chloroO-toluidine". Paragraph 0098-0099. . Retrieved 2021/10/05.
• 3、 -. "Preparation method of pyridine quinazoline intermediate (by machine translation)". Paragraph 0011; 0015; 0019; 0023; 0027; 0031. . Retrieved 2020/02/14.