Propanoic acid, 3-(methoxymethylphosphinyl)-, methyl ester

Base Information

• Chemical Name: Propanoic acid, 3-(methoxymethylphosphinyl)-, methyl ester
• CAS No.: 15090-26-3
• Molecular Formula: C6H13O4P
• Molecular Weight: 180.141
• Mol file: 15090-26-3.mol

Synonyms:

Chemical Property of Propanoic acid, 3-(methoxymethylphosphinyl)-, methyl ester

Chemical Property:

• PSA: 76.07000
• LogP: 0.71310

Purity/Quality:

3-(Methoxymethylphosphinyl)propanoicAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-(Methoxymethylphosphinyl)propanoic Acid Methyl Ester, can be used for the synthesis of enantiomers of Phoshinothricin, also known as Glufosinate Ammonium (G596950), which is a herbicide commonly used in plant molecular biology and plant tissue culture.

Technology Process of Propanoic acid, 3-(methoxymethylphosphinyl)-, methyl ester

There total 4 articles about Propanoic acid, 3-(methoxymethylphosphinyl)-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.5%

acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) + dimethyl methane phosphonate (756-79-6) → methyl 3-(methoxy-methylphosphinyl)propionate (15090-26-3)

Guidance literature:

In ethanol; ethyl methyl ether;

Reference yield: 95.6%

methanol (67-56-1) + 3-(methylchlorophosphoryl)propionyl chloride (15090-24-1) → methyl 3-(methoxy-methylphosphinyl)propionate (15090-26-3)

Guidance literature:

With ammonia; In toluene; at -30 - 20 ℃; for 14h; Temperature;

Reference yield: 94.3%

methanol (67-56-1) + 3-(methylbromophosphoryl)propionyl bromide → methyl 3-(methoxy-methylphosphinyl)propionate (15090-26-3)

Guidance literature:

With N,N-dimethyl-aniline; In benzene; at -20 - 20 ℃; for 14h;

upstream raw materials:

methanol

3-(methylchlorophosphoryl)propionyl chloride

acrylic acid methyl ester

dimethyl methane phosphonate

Downstream raw materials:

2-carboxyethyl-methyl-phosphinic acid

Refernces

• 1、 -. "4 - (hydroxy-(methyl) phosphinyl) - 2-oxo-butyric acid production process". Paragraph 0060; 0061; 0077; 0078; 0079; 0080; 0081. . Retrieved 2017/02/24.