ethyl 2-ethylisonicotinate

Base Information

• Chemical Name: ethyl 2-ethylisonicotinate
• CAS No.: 15862-61-0
• Molecular Formula: C10H13NO2
• Molecular Weight: 179.219
• Mol file: 15862-61-0.mol

Synonyms:2-Ethyl-isonicotinic acid ethyl ester;2-Aethyl-isonicotinsaeure-aethylester;ethyl 2-ethylpyridine-4-carboxylate;

Chemical Property of ethyl 2-ethylisonicotinate

Chemical Property:

• Boiling Point: 130-131 °C(Press: 23 Torr)
• PKA: 3.86±0.10(Predicted)
• PSA: 39.19000
• Density: 1.055±0.06 g/cm3(Predicted)
• LogP: 1.82070

Purity/Quality:

Ethyl 2-ethylisonicotinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-ethylisonicotinate

There total 6 articles about ethyl 2-ethylisonicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

ethyl 2-chloroisonicotinate (54453-93-9) → ethyl 2-ethylisonicotinate (15862-61-0)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; 2-(N,N-dimethylamino)ethanol; In tetrahydrofuran; at 85 ℃; for 1h;

DOI:10.1021/jm025513q

Reference yield:

2-ethyl-6-hydroxy-isonicotinic acid (54881-17-3) → ethyl 2-ethylisonicotinate (15862-61-0)

Guidance literature:

Multi-step reaction with 2 steps

1: POCl₃; PCl₅ / 140 °C / Behandeln des Reaktionsprodukts mit Aethanol

2: palladium/charcoal; ethanol; potassium acetate / Hydrogenation

With palladium on activated charcoal; ethanol; phosphorus pentachloride; potassium acetate; trichlorophosphate;

DOI:10.1002/hlca.19550380425

Reference yield:

2-ethylpyridine-4-carboxylic acid (3376-96-3) → ethyl 2-ethylisonicotinate (15862-61-0)

Guidance literature:

With sulfuric acid; In ethanol; for 64h; Heating / reflux;

upstream raw materials:

2-ethylpyridine-4-carboxylic acid

ethanol

2-ethyl-6-chloro-isonicotinic acid ethyl ester

ethyl 2-chloroisonicotinate

Downstream raw materials:

2-ethyl-4-pyridinecarbonitrile

2-ethylpyridine-4-carboxamide

Refernces

• 1、 Sato, Nagaaki,Takahashi, Toshiyuki,Shibata, Takunobu,Haga, Yuji,Sakuraba, Aya,Hirose, Masaaki,Sato, Miki,Nonoshita, Katsumasa,Koike, Yuko,Kitazawa, Hidefumi,Fujino, Naoko,Ishii, Yasuyuki,Ishihara, Akane,Kanatani, Akio,Fukami, Takehiro. "Design and synthesis of the potent, orally available, brain-penetrable arylpyrazole class of neuropeptide Y5 receptor antagonists". . p. 666 - 669. Retrieved 2007/10/03.