Diphenyl(trifluoromethyl)phosphane

Base Information

• Chemical Name: Diphenyl(trifluoromethyl)phosphane
• CAS No.: 1605-56-7
• Molecular Formula: C13H10F3P
• Molecular Weight: 254.191
• DSSTox Substance ID: DTXSID50500106
• Nikkaji Number: J2.243.168D
• Wikidata: Q82351468
• Mol file: 1605-56-7.mol

Synonyms:Diphenyl(trifluoromethyl)phosphane;1605-56-7;diphenyltrifluoromethylphosphine;SCHEMBL9777482;DTXSID50500106

Chemical Property of Diphenyl(trifluoromethyl)phosphane

Chemical Property:

• XLogP3: 4.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 254.04722180
• Heavy Atom Count: 17
• Complexity: 209

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)P(C2=CC=CC=C2)C(F)(F)F

Technology Process of Diphenyl(trifluoromethyl)phosphane

There total 16 articles about Diphenyl(trifluoromethyl)phosphane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

C7H18B4F3N2(1-)*K(1+) + chloro-diphenylphosphine (1079-66-9,74391-44-9) → (trifluoromethyl)-diphenylphosphine (1605-56-7)

Guidance literature:

In tetrahydrofuran; at 25 ℃; for 0.0833333h;

Reference yield: 85.0%

phenyl diphenylphosphinite (13360-92-4) + (trifluoromethyl)trimethylsilane (81290-20-2) → (trifluoromethyl)-diphenylphosphine (1605-56-7)

Guidance literature:

With cesium fluoride; In diethyl ether; at 20 ℃; for 18h; Inert atmosphere;

DOI:10.1039/c7cc09128a

Reference yield: 78.0%

Togni's reagent II (887144-94-7) + diphenylphosphane (829-85-6) → (trifluoromethyl)-diphenylphosphine (1605-56-7)

Guidance literature:

In dichloromethane; at 20 ℃; for 22h;

DOI:10.1039/b801424h

upstream raw materials:

(trifluoromethyl)trimethylsilane

diphenylcyanophosphine

phenyl diphenylphosphinite

sodium diphenylphosphide

Downstream raw materials:

diphenyl(methyl)phosphine oxide

Triphenylphosphine oxide

bis(triphenyl)oxodiphosphonium trifluoromethanesulfonate salt

triphenyl(trifluoromethyl)phosphonium trifluoromethanesulfonate

Refernces

• 1、 Krishnamurti, Vinayak,Barrett, Colby,Prakash, G. K. Surya. "Siladifluoromethylation and Deoxo-trifluoromethylation of PV-H Compounds with TMSCF3: Route to PV-CF2- Transfer Reagents and P-CF3 Compounds". supporting information. p. 1526 - 1529. Retrieved 2019/03/07.
• 2、 Fasano,LaFortune,Bayne,Ingleson,Stephan. "Air- and water-stable Lewis acids: Synthesis and reactivity of P-trifluoromethyl electrophilic phosphonium cations". supporting information. p. 662 - 665. Retrieved 2018/02/06.