4-MORPHOLINOBENZOYL CHLORIDE HYDROCHLORIDE

Base Information

• Chemical Name: 4-MORPHOLINOBENZOYL CHLORIDE HYDROCHLORIDE
• CAS No.: 162848-18-2
• Molecular Formula: C11H12ClNO2
• Molecular Weight: 225.675
• Hs Code.: 2934999090
• Mol file: 162848-18-2.mol

Synonyms:4-MORPHOLINOBENZOYL CHLORIDE;4-morpholin-4-yl-benzoyl chloride;4-MorpholinobenzoylchlorideHCl;

Chemical Property of 4-MORPHOLINOBENZOYL CHLORIDE HYDROCHLORIDE

Chemical Property:

• PSA: 29.54000
• LogP: 2.76920

Purity/Quality:

98%Min ^*data from raw suppliers

4-(Morpholin-4-yl)benzoyl chloride hydrochloride 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-MORPHOLINOBENZOYL CHLORIDE HYDROCHLORIDE

There total 4 articles about 4-MORPHOLINOBENZOYL CHLORIDE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.6%

4-morpholin-4-yl-benzoic acid (7470-38-4) → 4-(morpholin-4-yl)benzoyl chloride (162848-18-2)

Guidance literature:

With thionyl chloride; for 6h; Reflux;

DOI:10.1016/j.ejmech.2009.04.023

Reference yield:

4-bromophenyl-morpholine (30483-75-1) + butyryl chloride (141-75-3) → 4-(morpholin-4-yl)benzoyl chloride (162848-18-2)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In toluene; at 100 ℃; for 16h; Sealed tube; Inert atmosphere;

DOI:10.1002/anie.202005891

Reference yield:

oxalyl dichloride (79-37-8) + 4-morpholin-4-yl-benzoic acid (7470-38-4) → 4-(morpholin-4-yl)benzoyl chloride (162848-18-2)

Guidance literature:

In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

oxalyl dichloride

4-morpholin-4-yl-benzoic acid

4-bromophenyl-morpholine

butyryl chloride

Downstream raw materials:

bis-p-morpholinobenzoyl trisulfide

N-{4-[3-(4-Methoxyphenyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-ylamino]-phenyl}-4-morpholin-4-yl-benzamide

methyl 1-(4-morpholin-4-ylbenzoyl)-3-[(4-morpholin-4-ylbenzoyl)amino]-1H-thieno[3,2-c]pyrazole-5-carboxylate

N-ethyl-2-iodo-4-(morpholino)benzamide

Refernces

• 1、 Cheng, Maosheng,Liu, Nian,Lv, Ruicheng,Qin, Qiaohua,Sun, Yin,Sun, Yixiang,Wang, Ruifeng,Wang, Xiaoyan,Wu, Tianxiao,Yin, Wenbo,Zhang, Chu,Zhao, Dongmei. "Design, synthesis, biological evaluation and pharmacophore model analysis of novel tetrahydropyrrolo[3,4-c]pyrazol derivatives as potential TRKs inhibitors". . . Retrieved 2021/06/28.
• 2、 Bismuto, Alessandro,Boehm, Philip,Morandi, Bill,Roediger, Sven. "Palladium-Catalyzed Chlorocarbonylation of Aryl (Pseudo)Halides Through In Situ Generation of Carbon Monoxide". supporting information. p. 17887 - 17896. Retrieved 2020/08/19.