Methyl 2-AMino-2-(1-Boc-4-piperidyl)acetate

Base Information

• Chemical Name: Methyl 2-AMino-2-(1-Boc-4-piperidyl)acetate
• CAS No.: 177948-33-3
• Molecular Formula: C13H24N2O4
• Molecular Weight: 272.345
• Hs Code.: 2933399090
• Mol file: 177948-33-3.mol

Synonyms:ethyl 2-aminocyclohex-1-enecarboxylate;ethyl 2-aminocyclohex-1-ene-1-carboxylate;2-Amino-cyclohex-1-enecarboxylic acid ethyl ester;tert-Butyl 4-(1-amino-2-methoxy-2-oxoethyl)piperidine-1-carboxylate;ethyl 2-amino-1-cyclohexenecarboxylate;Ethyl 2-amino-1-cyclohexene-1-carboxylate;2-Amino-1-cyclohexenecarboxylic acid ethyl ester;

Chemical Property of Methyl 2-AMino-2-(1-Boc-4-piperidyl)acetate

Chemical Property:

• Boiling Point: 350.7±12.0 °C(Predicted)
• PKA: 7.36±0.50(Predicted)
• PSA: 81.86000
• Density: 1.116±0.06 g/cm3(Predicted)
• LogP: 1.77200
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

98%min ^*data from raw suppliers

tert-Butyl4-(1-amino-2-methoxy-2-oxoethyl)piperidine-1-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 2-AMino-2-(1-Boc-4-piperidyl)acetate

There total 7 articles about Methyl 2-AMino-2-(1-Boc-4-piperidyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.68%

4-(benzyloxycarbonylamino-methoxycarbonyl-methylene)-piperidine-1-carboxylic acid tert-butyl ester (313491-20-2) → tert-butyl 4-(1-amino-2-methoxy-2-oxoethyl)piperidine-1-carboxylate (177948-33-3)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 16h; under 760.051 Torr;

Reference yield:

tert-butyl 4-(1-azido-2-methoxy-2-oxoethyl)piperidine-1-carboxylate (1380344-28-4) → tert-butyl 4-(1-amino-2-methoxy-2-oxoethyl)piperidine-1-carboxylate (177948-33-3)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen;

DOI:10.1016/j.bmcl.2011.09.113

Reference yield:

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → tert-butyl 4-(1-amino-2-methoxy-2-oxoethyl)piperidine-1-carboxylate (177948-33-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 93.2 percent / diazabicycloundecane / CH₂Cl₂ / 2 h / 20 °C

2: H₂ / Pd/C / methanol / 12 h / 20 °C / 2327.23 Torr

With diazabicycloundecane; hydrogen; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1021/jm015531s

upstream raw materials:

4-(benzyloxycarbonylamino-methoxycarbonyl-methylene)-piperidine-1-carboxylic acid tert-butyl ester

N-tert-butyloxycarbonylpiperidin-4-one

N-(benzyloxycarbonyl)phosphonoglycine trimethyl ester

4-(bromo-methoxycarbonyl-methyl)-piperidine-1-carboxylic acid tert-butyl ester

Downstream raw materials:

C₂₁H₃₀N₄O

C₃₀H₃₆N₄O₂

C₃₀H₃₈N₄O₂

C₂₉H₃₆N₄O₂

Refernces

• 1、 -. "PROGRANULIN MODULATORS AND METHODS OF USING THE SAME". . . Retrieved 2021/04/30.
• 2、 -. "4-SUBSTITUTED-CYCLOHEXYLAMINO-4-PIPERIDINYL-ACETAMIDE ANTAGONISTS OF CCR2". . . Retrieved 2012/06/16.