2-TRIMETHYLSILYLMETHYLPYRIDINE

Base Information

• Chemical Name: 2-TRIMETHYLSILYLMETHYLPYRIDINE
• CAS No.: 17881-80-0
• Molecular Formula: C9H15NSi
• Molecular Weight: 165.31
• Hs Code.: 2933399090
• Mol file: 17881-80-0.mol

Synonyms:trimethyl-pyridin-2-ylmethyl-silane;picolyltrimethylsilane;2-TRIMETHYLSILYLMETHYLPYRIDINE;

Chemical Property of 2-TRIMETHYLSILYLMETHYLPYRIDINE

Chemical Property:

• PSA: 12.89000
• LogP: 2.76790

Purity/Quality:

99% ^*data from raw suppliers

2-TRIMETHYLSILYLMETHYLPYRIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-TRIMETHYLSILYLMETHYLPYRIDINE

There total 2 articles about 2-TRIMETHYLSILYLMETHYLPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

α-picoline (109-06-8) + bis-trimethylsilanyl peroxide (5796-98-5) → 2-Ethylpyridine (100-71-0) + (2-picolyl)trimethylsilane (17881-80-0) + 2-[(trimethysilyloxy)methyl]pyridine (56844-69-0)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 2h; alkylation of other heteroaryl alkyl metals;

DOI:10.1016/S0040-4020(01)90538-1

Reference yield:

2-chloromethylpyridine (4377-33-7) + chloro-trimethyl-silane (75-77-4) → (2-picolyl)trimethylsilane (17881-80-0)

Guidance literature:

With ; Yield given. Multistep reaction; 1.) THF, 20 deg C, 1 h, 2.) THF;

DOI:10.1021/jo00249a002

Reference yield: 30.0%

(2-picolyl)trimethylsilane (17881-80-0) + C,N-diphenylnitrone (201024-81-9) → Azobenzene (1227476-15-4) + azoxybenzene (495-48-7,55599-32-1) + 2-[(E)-2-phenylethenyl]pyridine (538-49-8)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; -75 deg C, 1 h; r.t., 1 h; r.t., 2 h;

DOI:10.1246/cl.1980.977

upstream raw materials:

α-picoline

bis-trimethylsilanyl peroxide

2-chloromethylpyridine

chloro-trimethyl-silane

Downstream raw materials:

Hexamethyldisiloxane

2-methylazinium (2,4,6)-trinitrophenolate

C₂₀H₁₄N₂O

1-(4-chlorophenyl)-2-(pyridin-2-yl)ethanone

Refernces

• 1、 Harvey, Stephen,Junk, Peter C.,Raston, Colin L.,Salem, Geoffrey. "Main Group Conjugated Organic Anion Chemistry. 3. Application of Magnesium-Anthracene Compounds in the Synthesis of Grignard Reagents". . p. 3134 - 3140. Retrieved 2007/10/02.