4,5-Diphenyl-1,3-thiazole

Base Information

• Chemical Name: 4,5-Diphenyl-1,3-thiazole
• CAS No.: 1826-15-9
• Molecular Formula: C15H11NS
• Molecular Weight: 237.325
• DSSTox Substance ID: DTXSID80356931
• Nikkaji Number: J3.078.375A
• Wikidata: Q82136573
• Mol file: 1826-15-9.mol

Synonyms:4,5-diphenylthiazole;Thiazole, 4,5-diphenyl-;1826-15-9;4,5-diphenyl-1,3-thiazole;Enamine_000636;SCHEMBL926914;DTXSID80356931;HMS1395M20;AKOS000521946;Z56772023

Chemical Property of 4,5-Diphenyl-1,3-thiazole

Chemical Property:

• XLogP3: 4.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 237.06122053
• Heavy Atom Count: 17
• Complexity: 231

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=C(SC=N2)C3=CC=CC=C3

Technology Process of 4,5-Diphenyl-1,3-thiazole

There total 14 articles about 4,5-Diphenyl-1,3-thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

N-(2-oxo-1,2-diphenylethyl)formamide (97195-28-3) → 4,5-diphenylthiazole (1826-15-9)

Guidance literature:

With Lawessons reagent; In tetrahydrofuran; Heating;

DOI:10.1016/j.tet.2004.03.037

Reference yield: 80.0%

methyl dithiobenzoate (2168-78-7) + Benzyl isocyanide (88333-03-3,10340-91-7) → 4,5-diphenylthiazole (1826-15-9)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 0.416667h;

DOI:10.1055/s-0031-1290762

Reference yield: 77.0%

4-phenyl-thiazole (1826-12-6) + iodobenzene (591-50-4) → 4,5-diphenylthiazole (1826-15-9)

Guidance literature:

With tert-Amyl alcohol; di-tert-butyl(methyl)phosphonium tetrafluoroborate salt; palladium diacetate; caesium carbonate; at 80 ℃; for 36h; regioselective reaction;

DOI:10.1039/c3sc52199k

upstream raw materials:

2-hydrazino-4,5-diphenyl-thiazole

2,5-diphenyl-1,3-thiazole

formaldehyd

Desyl chloride

Downstream raw materials:

2,4,5-triphenylthiazole

(diphenylthiazolyl)toluene

4-(4,5-diphenyl-thiazol-2-yl)-pyridine

Refernces

• 1、 Lingaraju, Gejjalagere S.,Swaroop, Toreshettahally R.,Vinayaka, Ajjampura C.,Sharath Kumar, Kothanahally S.,Sadashiva, Marilinganadoddi P.,Rangappa, Kanchugarakoppal S.. "An easy access to 4,5-disubstituted thiazoles via base-induced click reaction of active methylene isocyanides with methyl dithiocarboxylates". experimental part. p. 1373 - 1379. Retrieved 2012/06/30.
• 2、 Karimian, Khashayar,Mohtarami, Fatemeh,Askari, Massoud. "Mechanism of Base-catalysed Hydrogen-Deuterium Exchange in Thiazolium Ion: Evidence for the Involvement of a Tetrahedral Intermediate". . p. 1538 - 1543. Retrieved 2007/10/02.