Phosphorous acid, dimethyl phenyl ester

Base Information

• Chemical Name: Phosphorous acid, dimethyl phenyl ester
• CAS No.: 18351-42-3
• Molecular Formula: C8H11O3P
• Molecular Weight: 186.147
• Mol file: 18351-42-3.mol

Synonyms:

Chemical Property of Phosphorous acid, dimethyl phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phosphorous acid, dimethyl phenyl ester

There total 13 articles about Phosphorous acid, dimethyl phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.6%

methanol (67-56-1) + phosphorus trichloride (7719-12-2,52843-90-0) → dimethyl phenylphosphonite (18351-42-3) + diphenyl methylphosphonate (7526-26-3) + methoxybenzene (100-66-3)

Guidance literature:

phosphorus trichloride; phenol; at 65 - 250 ℃; for 4h;

methanol; at 204 - 260 ℃; for 2h; Product distribution / selectivity;

Reference yield: 93.0%

dimethyl N,N-diisopropylphosphoramidite (122194-07-4) + phenol (108-95-2,27073-41-2) → dimethyl phenylphosphonite (18351-42-3)

Guidance literature:

With 1H-tetrazole; In acetonitrile; at 20 ℃;

DOI:10.1039/b926818a

Reference yield: 91.8%

triphenyl phosphite (101-02-0) + phosphorous acid trimethyl ester (121-45-9) → phosphoric acid triphenyl ester (115-86-6) + dimethyl phenylphosphonite (18351-42-3) + diphenyl methylphosphonate (7526-26-3) + phenol (108-95-2,27073-41-2)

Guidance literature:

triphenyl phosphite; methyl iodide; at 20 - 240 ℃;

phosphorous acid trimethyl ester; at 210 - 260 ℃; for 4h; Product distribution / selectivity;

upstream raw materials:

methanol

phenyl phosphorodichloridite

dimethoxy(dimethylamino)phosphine

dimethoxy(diethylamino)phosphine

Downstream raw materials:

methyl phenyl methylphosphonate

2,2-Dimethoxy-5-methyl-3-methylene-2-phenoxy-2,3-dihydro-2λ⁵-[1,2]oxaphosphole

phosphorous acid trimethyl ester

methyl phosphite

Refernces

• 1、 -. "DIARYL ALKYLPHOSPHONATES AND METHODS FOR PREPARING SAME". Page/Page column 6. . Retrieved 2008/06/13.
• 2、 Turhanen, Petri A.,Ahlgren, Markku J.,Jaervinen, Tomi,Vepsaelaeinen, Jouko J.. "Bisphosphonate prodrugs. Synthesis and identification of (1-hydroxyethylidene)-1,1-bisphosphonic acid tetraesters by mass spectrometry, NMR spectroscopy and x-ray crystallography". . p. 115 - 133. Retrieved 2007/10/03.