ethyl 1-(2-ethoxy-2-oxoethyl)-2-oxocyclohexanecarboxylate

Base Information

• Chemical Name: ethyl 1-(2-ethoxy-2-oxoethyl)-2-oxocyclohexanecarboxylate
• CAS No.: 7251-30-1
• Molecular Formula: C13H20O5
• Molecular Weight: 256.299
• Mol file: 7251-30-1.mol

Synonyms:

Chemical Property of ethyl 1-(2-ethoxy-2-oxoethyl)-2-oxocyclohexanecarboxylate

Chemical Property:

• Vapor Pressure: 9.68E-05mmHg at 25°C
• Boiling Point: 338.7°C at 760 mmHg
• Flash Point: 146.3°C
• Density: 1.116g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 1-(2-ethoxy-2-oxoethyl)-2-oxocyclohexanecarboxylate

There total 6 articles about ethyl 1-(2-ethoxy-2-oxoethyl)-2-oxocyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

ethyl bromoacetate (105-36-2) + ethyl 2-oxocyclohexane carboxylate (1655-07-8) → (1-ethoxycarbonyl-2-oxo-cyclohexyl)-acetic acid ethyl ester (7251-30-1)

Guidance literature:

With aluminum oxide; potassium tert-butylate; for 6h;

Reference yield: 71.0%

6-Trimethylsilanyloxy-bicyclo[4.1.0]heptane-1,7-dicarboxylic acid diethyl ester (125211-81-6) → (1-ethoxycarbonyl-2-oxo-cyclohexyl)-acetic acid ethyl ester (7251-30-1) + 2,3-diethoxycarbonylcycloheptanone (125211-82-7)

Guidance literature:

In ethanol; at 60 ℃; for 24h;

DOI:10.1016/S0040-4039(00)99330-4

Reference yield:

ethyl 2-(trimethylsilyloxy)cyclohex-1-enecarboxylate (74063-89-1) → (1-ethoxycarbonyl-2-oxo-cyclohexyl)-acetic acid ethyl ester (7251-30-1)

Guidance literature:

Multi-step reaction with 2 steps

1: Cu(acac)2

2: 1M tetraethylammonium fluoride / tetrahydrofuran

With copper acetylacetonate; tetraethylammonium fluoride; In tetrahydrofuran;

DOI:10.1016/S0040-4039(00)99330-4

upstream raw materials:

ethyl 2-oxocyclohexane carboxylate

diazoacetic acid ethyl ester

6-Trimethylsilanyloxy-bicyclo[4.1.0]heptane-1,7-dicarboxylic acid diethyl ester

ethyl bromoacetate

Downstream raw materials:

2-oxo-7a-phenyl-hexahydro-benzofuran-3a-carboxylic acid ethyl ester

2-ethoxycarbonyl-6-ethoxycarbonylmethylcyclohexanone

(2-oxocyclohexyl)acetic acid

ethyl 3-bromo-1-ethoxycarbonyl-2-oxocyclohex-1-ylacetate

Refernces

• 1、 Ranu, Brindaban C.,Bhar, Sanjay. "Surface-mediated Solid-phase Reaction. Part 2. Highly Selective Mono- and Di-C-alkylation of 1,3-Dicarbonyl Compounds on the Surface of Alumina". . p. 365 - 368. Retrieved 2007/10/02.