Phosphine oxide, hexyldiphenyl-

Base Information

• Chemical Name: Phosphine oxide, hexyldiphenyl-
• CAS No.: 19259-70-2
• Molecular Formula: C18H23OP
• Molecular Weight: 286.354
• Hs Code.: 2902909090
• DSSTox Substance ID: DTXSID70446971
• Nikkaji Number: J1.169.063G
• Wikidata: Q82265730
• Mol file: 19259-70-2.mol

Synonyms:Phosphine oxide, hexyldiphenyl-;[hexyl(phenyl)phosphoryl]benzene;19259-70-2;(diphenylphosphoryl)hexan;hexyldiphenylphosphine oxide;SCHEMBL1726010;DTXSID70446971

Chemical Property of Phosphine oxide, hexyldiphenyl-

Chemical Property:

• Vapor Pressure: 9.22E-06mmHg at 25°C
• Boiling Point: 384.2oC at 760 mmHg
• Flash Point: 186.1oC
• PSA: 26.88000
• Density: 1.04g/cm3
• LogP: 4.58080
• XLogP3: 4.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 7
• Exact Mass: 286.148652351
• Heavy Atom Count: 20
• Complexity: 279

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCCCP(=O)(C1=CC=CC=C1)C2=CC=CC=C2

Technology Process of Phosphine oxide, hexyldiphenyl-

There total 17 articles about Phosphine oxide, hexyldiphenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-hexene (592-41-6,25067-06-5) + Diphenylphosphine oxide (4559-70-0) → n-hexyldiphenylphosphine oxide (19259-70-2)

Guidance literature:

With sodium carbonate; salicylaldehyde; In water; for 3h; Reagent/catalyst; Catalytic behavior; Irradiation;

DOI:10.1039/d1gc00374g

Reference yield: 87.0%

diphenyl-n-hexylphosphine (18298-00-5) → n-hexyldiphenylphosphine oxide (19259-70-2)

Guidance literature:

With dihydrogen peroxide; In methanol; at 20 ℃; for 1h; Schlenk technique; Inert atmosphere;

DOI:10.1016/j.tetlet.2020.152125

Reference yield: 86.0%

4-methylbenzenesulfonic acid n-hexylester (3839-35-8) + Diphenylphosphine oxide (4559-70-0) → n-hexyldiphenylphosphine oxide (19259-70-2)

Guidance literature:

With N,N,N,N,-tetramethylethylenediamine; lithium methanolate; In 1-methyl-pyrrolidin-2-one; at 40 ℃; for 24h;

DOI:10.1039/c7ra02766d

upstream raw materials:

diphenyl-n-hexylphosphine

bromobenzene

Hexylphenylphosphine oxide

1-iodo-butane

Downstream raw materials:

(1-Methylhexyl)diphenylphosphinoxid

(4RS,5RS;E)-5-diphenylphosphinoyldec-2-en-4-ol

(4RS,5SR;E)-5-diphenylphosphinoyldec-2-en-4-ol

(E)-5-diphenylphosphinoyldec-2-en-4-ol

Refernces

• 1、 Zhang, Mengyue,Ma, Zhichao,Du, Hongguang,Wang, Zhiqian. "Palladium-catalyzed C(sp3)–P(III) bond formation reaction with acylphosphines as phosphorus source". supporting information. . Retrieved 2020/06/29.
• 2、 Lyubina, Anna P.,Mironov, Vladimir F.,Pashirova, Tatiana N.,Sapunova, Anastasiia S.,Shaihutdinova, Zukhra M.,Tatarinov, Dmitry A.,Terekhova, Natalia V.,Voloshina, Alexandra D.,Zakharova, Lucia Ya.. "Design and synthesis of amphiphilic 2-hydroxybenzylphosphonium salts with antimicrobial and antitumor dual action". supporting information. . Retrieved 2020/05/19.