N,N'-Dihydroxyisophthalamide

Base Information

• Chemical Name: N,N'-Dihydroxyisophthalamide
• CAS No.: 20073-81-8
• Molecular Formula: C8H8N2O4
• Molecular Weight: 196.163
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID20341982
• Nikkaji Number: J227.682H
• Wikidata: Q82112497
• Mol file: 20073-81-8.mol

Synonyms:20073-81-8;N~1~,N~3~-dihydroxybenzene-1,3-dicarboxamide;N,N'-Dihydroxyisophthalamide;Isophthalic dihydroxamic acid;V9D;Isophthalohydroxamic acid;SCHEMBL11791484;DTXSID20341982;AKOS002321086

Chemical Property of N,N'-Dihydroxyisophthalamide

Chemical Property:

• PSA: 105.64000
• LogP: 1.07420
• XLogP3: -1
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 196.04840674
• Heavy Atom Count: 14
• Complexity: 209

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC(=C1)C(=O)NO)C(=O)NO

Technology Process of N,N'-Dihydroxyisophthalamide

There total 7 articles about N,N'-Dihydroxyisophthalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

dimethyl Isophthalate (1459-93-4) → benzene-1,3-dihydroxamic acid (20073-81-8)

Guidance literature:

With hydroxylamine hydrochloride; sodium hydroxide; In methanol; water; at 0 - 20 ℃; Inert atmosphere;

Reference yield: 92.0%

isophthalic acid (121-91-5) → benzene-1,3-dihydroxamic acid (20073-81-8)

Guidance literature:

isophthalic acid; With sulfuric acid; In ethanol; ethyl acetate; for 12h; Inert atmosphere; Reflux;

With hydroxylamine hydrochloride; sodium hydroxide; In water; at 0 - 20 ℃;

Reference yield: 90.0%

benzene-1,3-dicarbonyl dichloride (99-63-8) → benzene-1,3-dihydroxamic acid (20073-81-8)

Guidance literature:

With hydroxylamine hydrochloride; sodium carbonate; In water; ethyl acetate; at 0 - 20 ℃; Inert atmosphere;

upstream raw materials:

benzene-1,3-dicarbonyl dichloride

dimethyl Isophthalate

isophthalic acid

α,α,α,α',α',α'-hexamethoxy-m-toluene

Downstream raw materials:

5,5,5',5'-tetramethyl-3,3'-m-phenylene-bis-[1,4,2]dioxazole

m-phenylenediamine

O,O'-Bis(diphenylcarbamyl)-terephthalohydroxamat

Refernces

• 1、 Chiong, Jerika A.,Zhu, Jie,Bailey, Jake B.,Kalaj, Mark,Subramanian, Rohit H.,Xu, Wenqian,Cohen, Seth M.,Tezcan, F. Akif. "An Exceptionally Stable Metal-Organic Framework Constructed from Chelate-Based Metal-Organic Polyhedra". . p. 6907 - 6912. Retrieved 2020.
• 2、 Deshpande, Mukund V.,Kulkarni, Anand M.,Pathan, Ejaj K.,Prasanna, Nallaballe V. L.,Ramana, Chepuri V.. "NADP-dependent glutamate dehydrogenases in a dimorphic zygomycete Benjaminiella poitrasii: Purification, characterization and their evaluation as an antifungal drug target". . . Retrieved 2020/08/21.