2-Nitrophenoxyacetyl Chloride

Base Information

• Chemical Name: 2-Nitrophenoxyacetyl Chloride
• CAS No.: 20142-87-4
• Molecular Formula: C8H6ClNO4
• Molecular Weight: 215.593
• Hs Code.: 2918990090
• European Community (EC) Number: 678-265-2
• DSSTox Substance ID: DTXSID50462295
• Nikkaji Number: J208.776F
• Mol file: 20142-87-4.mol

Synonyms:2-Nitrophenoxyacetyl Chloride;20142-87-4;2-(2-nitrophenoxy)acetyl Chloride;(2-nitrophenoxy)acetyl chloride;Acetyl chloride, 2-(2-nitrophenoxy)-;2-NitrophenoxyacetylChloride;o-nitrophenoxyacetyl chloride;SCHEMBL922764;(o-Nitrophenoxy)acetyl chloride;AEWBGACGIKCIJH-UHFFFAOYSA-;2-(2-nitrophenoxy)acetylChloride;DTXSID50462295;BBL014868;MFCD00059822;STL197277;AKOS005173170;VS-04661;FT-0683330;N0236;T72038;A879812;InChI=1/C8H6ClNO4/c9-8(11)5-14-7-4-2-1-3-6(7)10(12)13/h1-4H,5H2

Chemical Property of 2-Nitrophenoxyacetyl Chloride

Chemical Property:

• Vapor Pressure: 0.000181mmHg at 25°C
• Melting Point: 43oC
• Boiling Point: 329.1oC at 760 mmHg
• Flash Point: 152.8oC
• PSA: 72.12000
• Density: 1.434g/cm3
• LogP: 2.26220
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 214.9985354
• Heavy Atom Count: 14
• Complexity: 228

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Nitrophenoxyacetyl Chloride ^*data from reagent suppliers

Safty Information:

• Statements: 34
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)[N+](=O)[O-])OCC(=O)Cl

Technology Process of 2-Nitrophenoxyacetyl Chloride

There total 9 articles about 2-Nitrophenoxyacetyl Chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-nitrophenoxyacetic acid (1878-87-1) → 2-(2-nitrophenoxy)acetyl chloride (20142-87-4)

Guidance literature:

With phosphorus pentachloride; toluene;

Reference yield:

2-hydroxynitrobenzene (88-75-5,78813-12-4) → 2-(2-nitrophenoxy)acetyl chloride (20142-87-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 33percent aq. NaOH / 1 h / Heating

2: SOCl₂ / CHCl₃ / 6 h / Heating

With sodium hydroxide; thionyl chloride; In chloroform;

Reference yield:

sodium o-nitrophenate (824-39-5) → 2-(2-nitrophenoxy)acetyl chloride (20142-87-4)

Guidance literature:

Multi-step reaction with 2 steps

1: ethyl acetate

2: thionyl chloride / 8 h / Heating

With thionyl chloride; In ethyl acetate;

upstream raw materials:

2-nitrophenoxyacetic acid

2-hydroxynitrobenzene

sodium o-nitrophenate

ethyl o-nitrophenoxyacetate

Downstream raw materials:

N-{N-[(2-nitro-phenoxy)-acetyl]-glycyl}-glycine

4-(4-dimethylamino-phenyl)-3-(2-nitro-phenoxy)-1-(5-phenyl-[1,3,4]thiadiazol-2-yl)-azetidin-2-one

2-(2-nitro-phenoxy)-N-(5-phenyl-[1,3,4]thiadiazol-2-yl)-acetamide

6β-[2-(2-nitro-phenoxy)-acetylamino]-penicillanic acid

Refernces

• 1、 Sun, Yong,Lu, Cui-Lin,Wang, Chang-Yuan,Wang, Rui-Rui,Liu, Ke-Xin,Yang, Liu-Meng,Zhen, Yu-Hong,Zhang, Hou-Li,Wang, Chao,Zheng, Yong-Tang,Ma, Xiao-Dong. "Identification of the novel N-phenylbenzenesulfonamide derivatives as potent HIV inhibitors". . p. 243 - 247. Retrieved 2015/03/30.
• 2、 He, Hong-Wu,Yuan, Jun-Lin,Peng, Hao,Chen, Ting,Shen, Ping,Wan, Shu-Qing,Lee, Yanjun,Tan, Hong-Liang,He, Ya-Hui,He, Jun-Bo,Li, Yan. "Studies of O,O-Dimethyl α-(2,4-Dichlorophenoxyacetoxy) ethylphosphonate (HW02) as a new herbicide. 1. Synthesis and herbicidal activity of HW02 and analogues as novel inhibitors of pyruvate dehydrogenase complex". scheme or table. p. 4801 - 4813. Retrieved 2011/12/04.