Benzenecarboximidoyl chloride, N-methyl-

Base Information

• Chemical Name: Benzenecarboximidoyl chloride, N-methyl-
• CAS No.: 21737-87-1
• Molecular Formula: C8H8ClN
• Molecular Weight: 153.611
• Mol file: 21737-87-1.mol

Synonyms:

Chemical Property of Benzenecarboximidoyl chloride, N-methyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenecarboximidoyl chloride, N-methyl-

There total 9 articles about Benzenecarboximidoyl chloride, N-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

N-methylbenzamide (88070-48-8) → N-methyl benzimidoyl chloride (21737-87-1)

Guidance literature:

With thionyl chloride; Heating;

DOI:10.1021/jo00177a032

Reference yield: 63.0%

N-methyl-acetamide (79-16-3) + N-methylbenzamide (88070-48-8) → N-methyl benzimidoyl chloride (21737-87-1)

Guidance literature:

With thionyl chloride; at 55 ℃; for 2h;

DOI:10.1021/jo01289a018

Reference yield:

N,N-dimethyl(chlorophenylmethylene)ammonium chloride (2397-26-4) → N,N-dimethylbenzylamine hydrochloride (1875-92-9) + N-methyl benzimidoyl chloride (21737-87-1)

Guidance literature:

With 2,6-dimethylpyridine; hydrogen; tris(2,6-difluorophenyl)borane triethylphosphine oxide; In chloroform-d1; at 70 ℃; for 18h; under 3000.3 Torr; Sealed tube;

DOI:10.1021/jacs.8b12997

upstream raw materials:

N-methylbenzamide

N,N-dimethylbenzamide

N-benzoyl-N-methylcarbamic acid chloride

N-methyl-acetamide

Downstream raw materials:

N-methyl-N'-phenylbenzamidine

N-methyl-N'-[2]naphthyl-benzamidine

N,N'-dimethylbenzoamidine

N,N'-dimethyl-N-phenyl-benzamidine

Refernces

• 1、 Manley, Peter J,Bilodeau, Mark T. "A mild method for the formation and in situ reaction of imidoyl chlorides: conversion of pyridine-1-oxides to 2-aminopyridine amides.". . p. 3127 - 3129. Retrieved 2002.
• 2、 Sitte, Nikolai A.,Bursch, Markus,Grimme, Stefan,Paradies, Jan. "Frustrated Lewis Pair Catalyzed Hydrogenation of Amides: Halides as Active Lewis Base in the Metal-Free Hydrogen Activation". supporting information. p. 159 - 162. Retrieved 2019/01/04.
• 3、 Ho, Jonathan Z.,Braun, Matthew P.. "Preparation of 14C-labeled 1,2,4-triazoles from [ 14C]-labeled tetrazoles via Diels-Alder reaction: Synthesis of 11β-hydroxysteroid dehydrogenenase type 1 (HSD1) inhibitors". scheme or table. p. 431 - 433. Retrieved 2011/04/24.