3-Fluoro-2-methyl-benzoic acid methyl ester

Base Information

• Chemical Name: 3-Fluoro-2-methyl-benzoic acid methyl ester
• CAS No.: 230301-81-2
• Molecular Formula: C9H9FO2
• Molecular Weight: 168.168
• Hs Code.: 2916399090
• Mol file: 230301-81-2.mol

Synonyms:Benzoic acid,3-fluoro-2-methyl-,methyl ester;3-Fluoro-2-methyl-benzoic acid methyl ester;

Chemical Property of 3-Fluoro-2-methyl-benzoic acid methyl ester

Chemical Property:

• Vapor Pressure: 0.185mmHg at 25°C
• Boiling Point: 211.2oC at 760 mmHg
• Flash Point: 79.5oC
• PSA: 26.30000
• Density: 1.137g/cm3
• LogP: 1.92070

Purity/Quality:

95%＋ ^*data from raw suppliers

Methyl3-fluoro-2-methylbenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Fluoro-2-methyl-benzoic acid methyl ester

There total 1 articles about 3-Fluoro-2-methyl-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

methanol (67-56-1) + 3-fluoro-2-methylbenzoic acid (699-90-1) → methyl 3-fluoro-2-methylbenzoate (230301-81-2)

Guidance literature:

boron trifluoride diethyl etherate; at 20 ℃; Inert atmosphere;

Reference yield: 99.0%

methyl 3-fluoro-2-methylbenzoate (230301-81-2) → 2-Bromomethyl-3-fluoro-benzoic acid methyl ester (142314-72-5)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; for 3h; Inert atmosphere; Reflux;

Reference yield: 81.0%

AIBN (2,2'-azobisisobutyronitril) + methyl 3-fluoro-2-methylbenzoate (230301-81-2) → 2-Bromomethyl-3-fluoro-benzoic acid methyl ester (142314-72-5)

Guidance literature:

With N-Bromosuccinimide; In tetrachloromethane; water;

upstream raw materials:

methanol

3-fluoro-2-methylbenzoic acid

Downstream raw materials:

2-[2-(4-bromophenyl)ethenyl]-3-fluorobenzoic acid

2-Bromomethyl-3-fluoro-benzoic acid methyl ester

(S)-3-cyclohexyl-2-(4-fluoro-1-oxo-1,3-dihydro-isoindol-2-yl)-N-[1-(2-methoxy-ethyl)-1H-pyrazol-3-yl]-propionamide

(S)-3-cyclohexyl-2-(4-fluoro-1-oxo-1,3-dihydro-isoindol-2-yl)-propionic acid methyl ester

Refernces

• 1、 -. "Spirocyclic tetrahydroquinazolines". Paragraph 1019; 1024-1026. . Retrieved 2021/07/11.
• 2、 -. "ISOINDOLINONE DERIVATIVES". Page/Page column 18. . Retrieved 2012/11/13.