Methyl N-phenylglycinate

Base Information

• Chemical Name: Methyl N-phenylglycinate
• CAS No.: 23284-84-6
• Molecular Formula: C9H11NO2
• Molecular Weight: 165.192
• Hs Code.: 2922499990
• Mol file: 23284-84-6.mol

Synonyms:Glycine, N-phenyl-, methyl ester;METHYL N-PHENYLGLYCINATE;

Chemical Property of Methyl N-phenylglycinate

Chemical Property:

• Melting Point: > 44?C (dec.)
• PSA: 38.33000
• LogP: 1.34450
• Storage Temp.: Room Temperature, under inert atmosphere
• Solubility.: Acetonitrile (Slightly), DMSO (Slightly)

Purity/Quality:

98.5% ^*data from raw suppliers

N-Phenyl-glycinemethylester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl N-phenylglycinate

There total 13 articles about Methyl N-phenylglycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methanol (67-56-1) + N-Phenylglycine (103-01-5) → N-phenylglycine methyl ester (23284-84-6)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃;

Reference yield: 88.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + N-Phenylglycine (103-01-5) → N-phenylglycine methyl ester (23284-84-6)

Guidance literature:

In diethyl ether; acetonitrile; at 20 ℃; for 0.5h;

DOI:10.1021/ja011648u

Reference yield: 87.0%

bromoacetic acid methyl ester (96-32-2) + aniline (62-53-3) → N-phenylglycine methyl ester (23284-84-6)

Guidance literature:

With potassium carbonate; potassium iodide; In acetone; at 20 - 60 ℃; for 12h; Inert atmosphere;

DOI:10.3998/ark.5550190.p008.138

upstream raw materials:

methyl chloroacetate

aniline

methanol

N-Phenylglycine

Refernces

• 1、 Song, Yang,Zhang, Hao,Guo, Jiabao,Shao, Yifei,Ding, Yuzhou,Zhu, Li,Yao, Xiaoquan. "Visible-Light-Induced Oxidative α-Alkylation of Glycine Derivatives with Ethers under Metal-Free Conditions". . p. 5914 - 5921. Retrieved 2021/11/22.
• 2、 Tian, Hao,Xu, Wentao,Liu, Yuxiu,Wang, Qingmin. "Unnatural α-Amino Acid Synthesized through α-Alkylation of Glycine Derivatives by Diacyl Peroxides". supporting information. p. 5005 - 5008. Retrieved 2020/07/04.