2-Chlorostilbene

Base Information

• Chemical Name: 2-Chlorostilbene
• CAS No.: 24942-76-5
• Molecular Formula: C14H11Cl
• Molecular Weight: 214.69
• Mol file: 24942-76-5.mol

Synonyms:

Chemical Property of 2-Chlorostilbene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Chlorostilbene

There total 95 articles about 2-Chlorostilbene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + 2-iodochlorobenzene (615-41-8) → (E)-2-chlorostilbene (1657-52-9,24942-76-5)

Guidance literature:

With potassium carbonate; In water; at 60 ℃; for 6h;

DOI:10.1016/j.tetlet.2012.05.046

Reference yield: 97.0%

iodobenzene (591-50-4) + (E)-[1-(2-chlorophenyl)-2-(1,1,3,3,3-pentamethyldisiloxy)]ethene (1326305-01-4) → (E)-2-chlorostilbene (1657-52-9,24942-76-5)

Guidance literature:

With [PdCl₂P(OCH₂CMe₂NH)OCH₂CMe₂NH₂]; tetrabutyl ammonium fluoride; In tetrahydrofuran; at 60 ℃; for 12h; diastereoselective reaction; Inert atmosphere;

DOI:10.1016/j.molcata.2011.09.025

Reference yield: 93.0%

bromobenzene (108-86-1,52753-63-6) + 2-ClC6H4CH=CHSiMe2OSiMe3 → (E)-2-chlorostilbene (1657-52-9,24942-76-5)

Guidance literature:

With PdCl₂{P(OCMe₂CMe₂O)OCH₂CMe₂NH₂}; tetrabutyl ammonium fluoride; In N,N-dimethyl-formamide; at 140 ℃; for 4h; stereoselective reaction; Inert atmosphere;

DOI:10.1016/j.jorganchem.2011.05.008

upstream raw materials:

(E)-3-(2-chlorophenyl)-2-phenyl-prop-2-enoic acid

o-chloroaniline

quinoline

2,4,6-trimethyl-pyridine

Downstream raw materials:

2-phenylbenzo[b]thiophene

(Z)-1-chloro-2-styrylbenzene

(2-chlorophenyl)(phenyl)methanone

1-(2-chlorophenyl)-2-phenylethane-1,2-dione

Refernces

• 1、 Watanabe, Hikaru,Nakajima, Kazuki,Ekuni, Kento,Edagawa, Ryota,Akagi, Yuta,Okuda, Yasuhiro,Wakamatsu, Kan,Orita, Akihiro. "Custom-Made Pyrene Photocatalyst-Promoted Desulfonylation of Arylethenyl Sulfones Using Green-Light-Emitting Diodes". . p. 2984 - 2994. Retrieved 2021/03/04.
• 2、 Sklyaruk, Jan,Zubar, Viktoriia,Borghs, Jannik C.,Rueping, Magnus. "Methanol as the Hydrogen Source in the Selective Transfer Hydrogenation of Alkynes Enabled by a Manganese Pincer Complex". supporting information. p. 6067 - 6071. Retrieved 2020/08/28.