N-Phenethyl-1-hexanamine

Base Information

• Chemical Name: N-Phenethyl-1-hexanamine
• CAS No.: 24997-83-9
• Molecular Formula: C14H23N
• Molecular Weight: 205.343
• Hs Code.: 2921199090
• Mol file: 24997-83-9.mol

Synonyms:hexyl(2-phenylethyl)amine;Phenethylamine,N-hexyl;hexylphenethylamine;N-(2-Phenylethyl)-1-hexanamine;N-phenethylhexan-1-amine;N-hexyl-2-phenylethylamine;Benzeneethanamine,N-hexyl;

Chemical Property of N-Phenethyl-1-hexanamine

Chemical Property:

• Boiling Point: 138 °C(Press: 6 Torr)
• PKA: 10.55±0.19(Predicted)
• PSA: 12.03000
• Density: 0.892±0.06 g/cm3(Predicted)
• LogP: 3.78990

Purity/Quality:

N-(2-Phenylethyl)hexan-1-amine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Phenethyl-1-hexanamine

There total 14 articles about N-Phenethyl-1-hexanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

hexan-1-amine (111-26-2) + phenylacetonitrile (140-29-4) → N-hexyl-2-phenylethylamine (24997-83-9) + diphenethylamine (6308-98-1)

Guidance literature:

With 3 % platinum on carbon; hydrogen; In toluene; at 105 ℃; under 4500.45 Torr; Flow reactor;

DOI:10.1039/c2cy20431b

Reference yield: 83.0%

1-hexyl acetate (142-92-7) + phenethylamine (64-04-0) → methyl-N-(benzyl-methyl)-formamide (877-95-2) + N-hexyl-2-phenylethylamine (24997-83-9)

Guidance literature:

With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; sodium acetate; In neat (no solvent); at 115 ℃; for 24h; Inert atmosphere; Glovebox; Green chemistry;

DOI:10.1002/adsc.201400319

Reference yield: 82.0%

hexanal (66-25-1) + phenethylamine (64-04-0) → N-hexyl-2-phenylethylamine (24997-83-9)

Guidance literature:

With 2-picoline borane complex; acetic acid; In methanol; at 20 ℃; for 1h;

DOI:10.1016/j.tet.2004.06.045

upstream raw materials:

Benzyl-hexyl-phenethyl-amine

hexanal

phenethylamine

Benzyl-butoxymethyl-hexyl-amine

Downstream raw materials:

ethyl (2S)-2-ethoxy-3-(4-{2-[hexyl-(2-phenylethyl)amino]-2-oxoethoxy}phenyl)propanoate

Refernces

• 1、 Zhang, Jianbo,Chang, Sukbok. "Cine-Silylative Ring-Opening of α-Methyl Azacycles Enabled by the Silylium-Induced C-N Bond Cleavage". supporting information. p. 12585 - 12590. Retrieved 2020/08/21.
• 2、 Enyong, Arrey B.,Moasser, Bahram. "Ruthenium-catalyzed N-alkylation of amines with alcohols under mild conditions using the borrowing hydrogen methodology". . p. 7553 - 7563. Retrieved 2014/09/17.