N-Acetylcyclopentane-1-amine

Base Information

• Chemical Name: N-Acetylcyclopentane-1-amine
• CAS No.: 25291-41-2
• Molecular Formula: C7H13NO
• Molecular Weight: 127.18400
• Hs Code.: 2924299090
• Mol file: 25291-41-2.mol

Synonyms:Acetamidocyclopentane;-cyclopentan;N-Cyclopentyl-acetamid;Acetamide,N-cyclopentyl;N-cyclopentyl-acetamide;1-acetamidocyclopentane;

Chemical Property of N-Acetylcyclopentane-1-amine

Chemical Property:

• PSA: 32.59000
• LogP: 1.90540

Purity/Quality:

99% ^*data from raw suppliers

N-?Cyclopentylacetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-?Cyclopentylacetamide is a derivative of 3-?Oxobutanenitrile (O869928) a reagent used in the synthesis of pyrazolopyrimidinones as well as in the preparation of inhibitors of phosphopantetheine.

Technology Process of N-Acetylcyclopentane-1-amine

There total 15 articles about N-Acetylcyclopentane-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

Benzyl acetate (140-11-4) + Cyclopentamine (1003-03-8) → N-cyclopentylacetamide (25291-41-2) + N-cyclopentylbenzylamine (15205-23-9)

Guidance literature:

With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; sodium acetate; In neat (no solvent); at 115 ℃; for 24h; Inert atmosphere; Glovebox; Green chemistry;

DOI:10.1002/adsc.201400319

Reference yield: 89.0%

Cyclopentanol (96-41-3) + acetonitrile (75-05-8,26809-02-9) → N-cyclopentylacetamide (25291-41-2)

Guidance literature:

With tropylium tetrafluoroborate; In water; at 150 ℃; for 1h; under 12001.2 Torr; Flow reactor;

DOI:10.1039/d1cc02947a

Reference yield: 83.0%

acetic anhydride (108-24-7) + Cyclopentamine (1003-03-8) → N-cyclopentylacetamide (25291-41-2)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

upstream raw materials:

acetic anhydride

Cyclopentamine

acetyl chloride

cyclopentene

Downstream raw materials:

cyclopentyl ethylamine hydrochloride

Refernces

• 1、 Doan, Son H.,Hussein, Mohanad A.,Nguyen, Thanh Vinh. "Tropylium-promoted Ritter reactions". supporting information. p. 8901 - 8904. Retrieved 2021/09/10.
• 2、 -. "Substituted benzimidazole derivatives". Paragraph 0042; 0044; 0045; 0142. . Retrieved 2018/01/09.