N, N-Bis(phenylmethyl)hexanediamide

Base Information

• Chemical Name: N, N-Bis(phenylmethyl)hexanediamide
• CAS No.: 25344-24-5
• Molecular Formula: C20H24N2O2
• Molecular Weight: 324.423
• European Community (EC) Number: 636-749-0
• UNII: Y359L3Y8LU
• DSSTox Substance ID: DTXSID10179993
• Nikkaji Number: J782.093C
• Wikidata: Q27294203
• Mol file: 25344-24-5.mol

Synonyms:N,N'-Dibenzyladipamide;N, N-Bis(phenylmethyl)hexanediamide;25344-24-5;UNII-Y359L3Y8LU;Y359L3Y8LU;N,N'-bis(phenylmethyl)hexanediamide;N,N'-dibenzylhexanediamide;N,N'-DBAA;SCHEMBL2942358;N-bis(phenylmethyl)hexanediamideN;DTXSID10179993;AKOS003410098;HEXANEDIAMIDE, N,N'-DIBENZYL-;Hexanediamide, N,N'-bis(phenylmethyl)-;HEXANEDIAMIDE, N1,N6-BIS(PHENYLMETHYL)-;Q27294203

Chemical Property of N, N-Bis(phenylmethyl)hexanediamide

Chemical Property:

• XLogP3: 2.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 9
• Exact Mass: 324.183778013
• Heavy Atom Count: 24
• Complexity: 336

Purity/Quality:

98%Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CNC(=O)CCCCC(=O)NCC2=CC=CC=C2

Technology Process of N, N-Bis(phenylmethyl)hexanediamide

There total 9 articles about N, N-Bis(phenylmethyl)hexanediamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

Adipic acid dichloride (111-50-2) + benzylamine (100-46-9) → N1,N6-dibenzyladipamide (25344-24-5)

Guidance literature:

With pyridine; cooling;

DOI:10.1007/s00706-004-0218-2

Reference yield: 61.0%

hexanedinitrile (111-69-3) + benzylamine (100-46-9) → N1,N6-dibenzyladipamide (25344-24-5)

Guidance literature:

With water; In 1,2-dimethoxyethane; at 160 ℃; for 18h;

DOI:10.1016/S0040-4039(00)00181-7

Reference yield: 10.0%

N-benzylacrylamide (13304-62-6) → N1,N6-dibenzyladipamide (25344-24-5)

Guidance literature:

With samarium diiodide; In tetrahydrofuran; at -78 ℃; for 17h;

DOI:10.1016/j.tet.2003.07.016

upstream raw materials:

Adipic acid

benzylamine

gloutaric dichloride

diethyl adipate

Downstream raw materials:

N,N'-Dibenzyl-N',N'''-bis-(p-chlorphenyl)-hexandiamidin

N,N'-dibenzyl-1,6-diaminohexane

N,N',N',N'''-Tetrabenzyl-hexandiamidin

N,N'-Dibenzyl-N',N'''-diphenethyl-hexandiamidin

Refernces

• 1、 Adamovskyi, Mykhailo I.,Ryabukhin, Sergey V.,Sibgatulin, Dmitriy A.,Rusanov, Eduard,Grygorenko, Oleksandr O.. "Beyond the five and six: Evaluation of seven-membered cyclic anhydrides in the castagnoli-cushman reaction". supporting information. p. 130 - 133. Retrieved 2017/09/08.
• 2、 Cobley, Christopher J.,Van Den Heuvel, Marco,Abbadi, Abdelilah,De Vries, Johannes G.. "Platinum catalysed hydrolytic amidation of unactivated nitriles". . p. 2467 - 2470. Retrieved 2007/10/03.