2,5-DIMETHOXY-4-METHYL-BETA-NITROSTYRENE, >95%

Base Information

• Chemical Name: 2,5-DIMETHOXY-4-METHYL-BETA-NITROSTYRENE, >95%
• CAS No.: 25505-64-0
• Molecular Formula: C11H13NO4
• Molecular Weight: 223.229
• Hs Code.: 2909309090
• Mol file: 25505-64-0.mol

Synonyms:Benzene, 1,4-dimethoxy-2-methyl-5-(2-nitroethenyl)- (en);

Chemical Property of 2,5-DIMETHOXY-4-METHYL-BETA-NITROSTYRENE, >95%

Chemical Property:

• Melting Point: 126 °C
• Boiling Point: 363.0±37.0 °C(Predicted)
• PSA: 64.28000
• Density: 1.168±0.06 g/cm3(Predicted)
• LogP: 2.78280
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), Dichloromethane (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

2,5-Dimethoxy-4-methyl-β-nitrostyrene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,5-DiMethoxy-4-Methyl-β-nitrostyrene is used in the preparation of phenylamine derivative as psychotomimetic agents.

Technology Process of 2,5-DIMETHOXY-4-METHYL-BETA-NITROSTYRENE, >95%

There total 4 articles about 2,5-DIMETHOXY-4-METHYL-BETA-NITROSTYRENE, >95% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

nitromethane (75-52-5) + 2,5-dimethoxy-4-methylbenzaldehyde (4925-88-6) → 1-(2,5-dimethoxy-4-methylphenyl)-2-nitroethene (25505-64-0)

Guidance literature:

With ammonium acetate; In benzene;

DOI:10.1021/jm00295a034

Reference yield:

2-methylbenzene-1,4-diol (95-71-6,96937-50-7) → 1-(2,5-dimethoxy-4-methylphenyl)-2-nitroethene (25505-64-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 82 percent / potassium hydroxide / methanol / 8 h / steam distillation

2: 1) HCl, aluminium chloride 2) aqueous H₂SO₄ / 1) tetrachloroethane, 8 h, 65-70 deg C 2) overnight, room temperature 3) steam distillation

3: 1) KOH 2) acetic anhydride, sodium acetate / 1) ethanol, water, 5 deg C, 2 days 2) reflux, 20 min.

With hydrogenchloride; potassium hydroxide; aluminium trichloride; sulfuric acid; sodium acetate; acetic anhydride; In methanol;

Reference yield:

2,5-dimethoxy toluene (24599-58-4) → 1-(2,5-dimethoxy-4-methylphenyl)-2-nitroethene (25505-64-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) HCl, aluminium chloride 2) aqueous H₂SO₄ / 1) tetrachloroethane, 8 h, 65-70 deg C 2) overnight, room temperature 3) steam distillation

2: 1) KOH 2) acetic anhydride, sodium acetate / 1) ethanol, water, 5 deg C, 2 days 2) reflux, 20 min.

With hydrogenchloride; potassium hydroxide; aluminium trichloride; sulfuric acid; sodium acetate; acetic anhydride;

upstream raw materials:

nitromethane

2,5-dimethoxy-4-methylbenzaldehyde

2-methylbenzene-1,4-diol

2,5-dimethoxy toluene

Downstream raw materials:

N,N-Diethyl-3-(2,5-dimethoxy-4-methylphenyl)-4-nitrobutyramid

3-(2,5-Dimethoxy-4-methylphenyl)-N,N-dimethyl-4-nitrobutyramid

2,5-dimethoxy-4-methyl-β-phenethylamine hydrochloride

2,4-Di-(2,5-dimethoxy-4-methylphenyl)-1,3-dinitrobutan

Refernces

• 1、 Ho,Tansey,Balster,An,McIsaac,Harris. "Amphetamine analogs. II. Methylated phenethylamines.". . p. 134 - 135. Retrieved 2007/10/06.