4925-88-6Relevant articles and documents
Seven-membered ring compound and application thereof in prevention and treatment of diabetes and metabolic syndrome
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Paragraph 0188-0192, (2020/06/09)
The invention discloses a seven-membered ring compound and application thereof in prevention and treatment of diabetes and metabolic syndrome. The structure of the seven-membered ring compound is as shown in a general formula I, and definitions of substituent groups are as shown in the specification and claims. The seven-membered ring compound of the invention has an extremely excellent effect ofpreventing or treating diabetes and metabolic syndrome.
LIPIDS AND LIPID COMPOSITIONS FOR THE DELIVERY OF ACTIVE AGENTS
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Page/Page column 81, (2016/03/19)
This invention provides for a compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein RA, RB, R2 and R4 are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.
Total synthesis of natural enantiomers of heliespirones A and C via the diastereoselective intramolecular Hosomi-Sakurai reaction
Miyawaki, Akari,Kikuchi, Daisuke,Niki, Masu,Manabe, Yuki,Kanematsu, Makoto,Yokoe, Hiromasa,Yoshida, Masahiro,Shishido, Kozo
, p. 8231 - 8243 (2013/01/15)
A full account of the development of a novel type of the intramolecular Hosomi-Sakurai reactions of the substrates with a pbenzoquinone and an allylsilane moieties connected by an ether linkage is described. This transformation proceeds via an addition-elimination sequence and provides the products with two stereogenic centers through a 1,3(or 1,4)-asymmetric induction in good to excellent diastereoselectivities. A reasonable mechanistic possibility for the reaction, determination of the stereochemistry for the product, and scope and limitation of the transformation are also discussed. The methodology developed here can successfully be applied to the enantiocontrolled total synthesis of the natural enantiomers of (-)-heliespirone A and (+)-heliespirone C, which have been isolated from sunflower Helianthus annuus L. as allelochemicals.