2-(2-Iodophenyl)ethan-1-ol

Base Information

• Chemical Name: 2-(2-Iodophenyl)ethan-1-ol
• CAS No.: 26059-40-5
• Molecular Formula: C8H9IO
• Molecular Weight: 248.063
• Mol file: 26059-40-5.mol

Synonyms:Benzeneethanol,2-iodo;2-iodophenyl ethanol;o-iodophenethyl alcohol;2-(2'-iodophenyl)ethanol;2-iodobenzeneethanol;2-(2-Iodophenyl)ethan-1-ol;

Chemical Property of 2-(2-Iodophenyl)ethan-1-ol

Chemical Property:

• Boiling Point: 136 °C(Press: 4 Torr)
• PKA: 14.73±0.10(Predicted)
• PSA: 20.23000
• Density: 1.7371 g/cm3(Temp: 25 °C)
• LogP: 1.82600
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

95% ^*data from raw suppliers

2-(2-Iodophenyl)ethanol 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2-Iodophenyl)ethan-1-ol

There total 16 articles about 2-(2-Iodophenyl)ethan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

o-iodophenylacetic acid (18698-96-9) → 2-(2-iodophenyl)ethan-1-ol (26059-40-5)

Guidance literature:

o-iodophenylacetic acid; With sodium tetrahydroborate; boron trifluoride diethyl etherate; In tetrahydrofuran; at 0 ℃; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; methanol; water; Inert atmosphere;

DOI:10.1021/ja5026276

Reference yield: 60.0%

2-aminophenethyl alcohol (5339-85-5) → 2-(2-iodophenyl)ethan-1-ol (26059-40-5)

Guidance literature:

2-aminophenethyl alcohol; With toluene-4-sulfonic acid; In water; Inert atmosphere;

With sodium nitrite; In water; Inert atmosphere;

With potassium iodide; In water; Inert atmosphere;

DOI:10.1021/acs.orglett.7b00402

Reference yield:

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) → 2-(2-iodophenyl)ethan-1-ol (26059-40-5) + acetophenone (98-86-2)

Guidance literature:

With aluminum oxide; periodic acid; In 1,4-dioxane; at 20 ℃; for 3h;

DOI:10.1016/j.tetlet.2006.03.102

upstream raw materials:

2-aminophenethyl alcohol

o-iodophenylacetic acid

o-iodostyrene

copper(I) cyanide

Downstream raw materials:

2-(2-chlorophenyl)-1-ethanol

2-(2-Iodophenyl)ethyl 4-toluenesulfonate

2-(o-iodophenethyl) diphenylphosphinite

2-(2'-bromoethyl)-1-iodobenzene

Refernces

• 1、 Garrido-Castro, Alberto F.,Salaverri, Noelia,Maestro, M. Carmen,Alemán, José. "Intramolecular Homolytic Substitution Enabled by Photoredox Catalysis: Sulfur, Phosphorus, and Silicon Heterocycle Synthesis from Aryl Halides". supporting information. p. 5295 - 5300. Retrieved 2019/07/03.
• 2、 Xiao, Jian,Cong, Xiao-Wei,Yang, Gui-Zhen,Wang, Ya-Wen,Peng, Yu. "Stereoselective synthesis of a: Podophyllum lignan core by intramolecular reductive nickel-catalysis". . p. 2040 - 2043. Retrieved 2018/03/01.