(3Z)-3-[(4-hydroxyphenyl)methylidene]-5,6-dimethoxy-1H-indol-2-one

Base Information

• Chemical Name: (3Z)-3-[(4-hydroxyphenyl)methylidene]-5,6-dimethoxy-1H-indol-2-one
• CAS No.: 269730-03-2
• Molecular Formula: C17H15NO4
• Molecular Weight: 297.30500
• European Community (EC) Number: 633-053-9
• UNII: LJ66VPR7DB
• Nikkaji Number: J1.290.351K
• Mol file: 269730-03-2.mol

Synonyms:RPI-1;269730-03-2;RPI1;RPI 1;LJ66VPR7DB;RPI 1 [WHO-DD];1,3-Dihydro-3-[(4-hydroxyphenyl)methylene]-5,6-dimethoxy-2H-indol-2-one;1,3-Dihydro-3-((4-hydroxyphenyl)methylene)-5,6-dimethoxy-2H-indol-2-one;2H-Indol-2-one, 1,3-dihydro-3-((4-hydroxyphenyl)methylene)-5,6-dimethoxy-;2H-Indol-2-one, 1,3-dihydro-3-[(4-hydroxyphenyl)methylene]-5,6-dimethoxy-;UNII-LJ66VPR7DB;SCHEMBL4100999;649758-61-2;BCP08977;EX-A2374;MFCD03852474;CID 1749978;RPI-1, >=98% (HPLC);NCGC00480825-02;AC-36047;AS-35238;HY-101246;CS-0021033;R0202;A13832;J-016636;(Z)-3-(4-hydroxybenzylidene)-5,6-dimethoxyindolin-2-one;5,6-Dimethoxy-3-[(4-hydroxyphenyl)methylene]-1H-indole-2(3H)-one;1,3-Dihydro-5,6-dimethoxy-3-[(4-hydroxyphenyl)methylene]-1H-indol-2-one

Chemical Property of (3Z)-3-[(4-hydroxyphenyl)methylidene]-5,6-dimethoxy-1H-indol-2-one

Chemical Property:

• PSA: 67.79000
• LogP: 3.04010
• Storage Temp.: 2-8°C
• Solubility.: DMSO: >20mg/mL
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 297.10010796
• Heavy Atom Count: 22
• Complexity: 442

Purity/Quality:

99.3% ^*data from raw suppliers

RPI 1 ^*data from reagent suppliers

Safty Information:

• Hazard Codes: N
• Statements: 50/53
• Safety Statements: 60-61

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C2C(=C1)C(=CC3=CC=C(C=C3)O)C(=O)N2)OC
• Isomeric SMILES: COC1=C(C=C2C(=C1)/C(=C/C3=CC=C(C=C3)O)/C(=O)N2)OC
• Uses: RPI-?1 is RET kinase inhibitor. It can be used in biological study of composition and function of mutant Swi?/Snf complexes. It can also be used in biological study of proteomics study of medullary thyroid carcinomas expressing RET germ-line mutations and identification of new signaling elements.

Technology Process of (3Z)-3-[(4-hydroxyphenyl)methylidene]-5,6-dimethoxy-1H-indol-2-one

There total 1 articles about (3Z)-3-[(4-hydroxyphenyl)methylidene]-5,6-dimethoxy-1H-indol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.6%

5,6-dimethoxy-2-indolinone (6286-64-2) + 4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → RPI-1 (649758-61-2,269730-03-2)

Guidance literature:

5,6-dimethoxy-2-indolinone; 4-hydroxy-benzaldehyde; With piperidine; In dimethyl sulfoxide; at 20 ℃; for 16h;

With hydrogenchloride; water; In dimethyl sulfoxide; at 5 - 10 ℃; for 1h;

upstream raw materials:

5,6-dimethoxy-2-indolinone

4-hydroxy-benzaldehyde

Refernces

• 1、 -. "Indolinone derivatives". Page/Page column 7. . Retrieved 2008/06/13.