MK-2

Base Information

• Chemical Name: MK-2
• CAS No.: 7421-23-0
• Molecular Formula: C21H24 O2
• Molecular Weight: 308.42
• Mol file: 7421-23-0.mol

Synonyms:1,4-Naphthalenedione,2-(3,7-dimethyl-2,6-octadienyl)-3-methyl-, (E)-; 1,4-Naphthalenedione,2-[(2E)-3,7-dimethyl-2,6-octadienyl]-3-methyl- (9CI); 1,4-Naphthoquinone,2-(3,7-dimethyl-2,6-octadienyl)-3-methyl-, (E)- (8CI); 1,4-Naphthoquinone,2-geranyl-3-methyl- (6CI); MK 2; Menaquinone 2; Vitamin K2(10); Vitamin MK 2;trans-Menaquinone-2

Chemical Property of MK-2

Chemical Property:

• Melting Point: 52-53 °C(Solv: acetone (67-64-1); ethanol (64-17-5))
• Boiling Point: 448.6±45.0 °C(Predicted)
• PSA: 34.14000
• Density: 1.045±0.06 g/cm3(Predicted)
• LogP: 5.46490
• Storage Temp.: -20°C

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of MK-2

There total 1 articles about MK-2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trans-geranyl bromide (6138-90-5) + 2-Bromo-3-Methyl-1,1,4,4-tetramethoxy-1,4-dihydronaphthalene (64648-85-7) → menadione (58-27-5,34524-96-4) + trans-2-methyl-3-(3′,7′-dimethylocta-2′,6′-dienyl)-1,4-naphthoquinone (7421-23-0)

Guidance literature:

With hydrogenchloride; n-butyllithium; copper (I) iodide; dimethylsulfide; water; Yield given. Multistep reaction. Yields of byproduct given;

DOI:10.1021/jo01291a002

Reference yield:

trans-2-methyl-3-(3′,7′-dimethylocta-2′,6′-dienyl)-1,4-naphthoquinone (7421-23-0) → 3-(5-carboxy-3-methyl-(2E)-penten-1-yl)-2-methyl-1,4-naphthoquinone (34185-71-2,51732-61-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 - 20 °C / Inert atmosphere

2: periodic acid / water; tetrahydrofuran-d8 / 1 h / 20 °C / Inert atmosphere

3: oxone / N,N-dimethyl-formamide / 2.5 h / 20 °C / Inert atmosphere

With oxone; periodic acid; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran-d8; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1055/s-0034-1380002

Reference yield:

trans-2-methyl-3-(3′,7′-dimethylocta-2′,6′-dienyl)-1,4-naphthoquinone (7421-23-0) → 2-((2E,6E)-8-((4-fluorophenyl)amino)-3,7-dimethylocta-2,6-dien-1-yl)-3-methylnaphthalene-1,4-dione

Guidance literature:

Multi-step reaction with 3 steps

1.1: selenium(IV) oxide; salicylic acid; tert.-butylhydroperoxide

2.1: manganese(IV) oxide

3.1: acetic acid / dichloromethane / 0.5 h / 20 °C / Molecular sieve; Inert atmosphere

3.2: 0 - 20 °C / Inert atmosphere

With tert.-butylhydroperoxide; manganese(IV) oxide; selenium(IV) oxide; acetic acid; salicylic acid; In dichloromethane;

DOI:10.1021/acs.jmedchem.6b01717

upstream raw materials:

trans-geranyl bromide

2-Bromo-3-Methyl-1,1,4,4-tetramethoxy-1,4-dihydronaphthalene

Downstream raw materials:

3-(5-carboxy-3-methyl-(2E)-penten-1-yl)-2-methyl-1,4-naphthoquinone

Refernces