2-(Diethylamino)-N,N-diethylacetamide

Base Information

• Chemical Name: 2-(Diethylamino)-N,N-diethylacetamide
• CAS No.: 27794-54-3
• Molecular Formula: C10H22N2O
• Molecular Weight: 186.297
• DSSTox Substance ID: DTXSID50537952
• Nikkaji Number: J2.193.990K
• Wikidata: Q82413134
• Mol file: 27794-54-3.mol

Synonyms:2-(Diethylamino)-N,N-diethylacetamide;27794-54-3;N,N-Diethyl-2-(diethylamino)acetamide;Acetamide, 2-(diethylamino)-N,N-diethyl-;SCHEMBL10795986;DTXSID50537952;N,N,N~2~,N~2~-Tetraethylglycinamide

Chemical Property of 2-(Diethylamino)-N,N-diethylacetamide

Chemical Property:

• XLogP3: 1.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 6
• Exact Mass: 186.173213330
• Heavy Atom Count: 13
• Complexity: 140

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN(CC)CC(=O)N(CC)CC

Technology Process of 2-(Diethylamino)-N,N-diethylacetamide

There total 3 articles about 2-(Diethylamino)-N,N-diethylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

carbon monoxide (201230-82-2) + diethylamine (109-89-7) + 1,1-dibromomethane (74-95-3) → diethylacetamide (685-91-6) + N,N-diethyl-2-diethylaminoacetamide (27794-54-3) + N,N,N',N'-tetraethylmalonamide (33931-42-9)

Guidance literature:

With triethylamine; dicobalt octacarbonyl; In hexane; at 100 ℃; for 48h; under 38000 Torr; Yield given. Yields of byproduct given; K₂CO₃, other solvents;

DOI:10.1016/S0040-4039(00)74885-4

Reference yield:

dichloromethane (75-09-2) + carbon monoxide (201230-82-2) + diethylamine (109-89-7) → diethylacetamide (685-91-6) + N,N-diethyl-2-diethylaminoacetamide (27794-54-3) + N,N,N',N'-tetraethylmalonamide (33931-42-9)

Guidance literature:

With potassium carbonate; dicobalt octacarbonyl; at 100 ℃; for 48h; under 38000 Torr; Yield given. Yields of byproduct given;

DOI:10.1016/S0040-4039(00)74885-4

Reference yield:

ethylmagnesium bromide (925-90-6) + 2-Chloro-N,N-diethylacetamide (2315-36-8) → 2-Ethylbutyraldehyde (97-96-1) + 3-diethylaminomethyl-pentan-3-ol (23590-25-2) + diethyl-(2-ethyl-but-2-enyl)-amine + N,N-diethyl-2-diethylaminoacetamide (27794-54-3)

Guidance literature:

upstream raw materials:

ethylmagnesium bromide

2-Chloro-N,N-diethylacetamide

dichloromethane

carbon monoxide

Downstream raw materials:

2-Diaethylamino-1,1-diphenyl-aethanol-(1)

Refernces