Isobenzofuran,octahydro-

Base Information

• Chemical Name: Isobenzofuran,octahydro-
• CAS No.: 4743-54-8
• Molecular Formula: C8H14 O
• Molecular Weight: 126.199
• Mol file: 4743-54-8.mol

Synonyms:Phthalan,hexahydro- (6CI,7CI,8CI); 1',2',3',4',5',6'-Hexahydrobenzofuran;2-Oxahydrindan; 3,4-(Tetramethylene)tetrahydrofuran; 8-Oxabicyclo[4.3.0]nonane

Chemical Property of Isobenzofuran,octahydro-

Chemical Property:

• Boiling Point: 62 °C(Press: 15 Torr)
• PSA: 9.23000
• Density: 0.9790 g/cm3
• LogP: 1.82300

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Isobenzofuran,octahydro-

There total 2 articles about Isobenzofuran,octahydro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,3-dihydroisobenzofuran (496-14-0) → 8-oxabicyclo[4.3.0]nonane (4743-54-8) + o-xylene (95-47-6) + 1,2-Dimethyl-cyclohexane (583-57-3) + (2-Methylcyclohexyl)methanol (2105-40-0)

Guidance literature:

at 250 ℃; under 88260.9 Torr; Hydrogenation;

DOI:10.1021/ja01122a048

Reference yield:

trans-1-methoxymethyl-2-hydroxymethylcyclohexane (137303-14-1) → trans-1-methoxymethyl-2-chloromethylcyclohexane (137303-15-2) + cis-8-oxabicyclo<4.3.0>nonane (13149-01-4,1158650-41-9) + trans-8-oxabicyclo<4.3.0>nonane (4743-54-8,10479-79-5,13149-01-4)

Guidance literature:

With thionyl chloride; at 90 - 95 ℃; for 1h;

DOI:10.1007/BF01172270

Reference yield: 31.0%

8-oxabicyclo[4.3.0]nonane (4743-54-8) + 4-diazo-2-phenylisoquinoline-1,3(2H,4H)-dione → 2′-phenyl-1′H-spiro[isochromane-3,4′-isoquinoline]-1′,3′(2′H)-dione

Guidance literature:

With dirhodium tetraacetate; at 100 ℃; for 2h; Inert atmosphere; Sealed tube; Microwave irradiation;

DOI:10.1021/acs.joc.9b00245

upstream raw materials:

trans-1-methoxymethyl-2-hydroxymethylcyclohexane

1,3-dihydroisobenzofuran

Downstream raw materials:

1-(Diethyl-methyl-silanyloxymethyl)-2-[(Z)-2-(diethyl-methyl-silanyloxy)-vinyl]-cyclohexane

1-(Diethyl-methyl-silanyloxymethyl)-2-[(E)-2-(diethyl-methyl-silanyloxy)-vinyl]-cyclohexane

trans-1,2-bis(bromomethyl)cyclohexane

(1S,6R)-8-oxabicyclo[4.3.0]nonan-7-one

Refernces