1-Acetyl-1-methylcyclohexane

Base Information

• Chemical Name: 1-Acetyl-1-methylcyclohexane
• CAS No.: 2890-62-2
• Molecular Formula: C9H16O
• Molecular Weight: 140.225
• Mol file: 2890-62-2.mol

Synonyms:methyl 1-methylcyclohexyl ketone;1-Methyl-hexahydroacetophenon;Ethanone, 1-(1-methylcyclohexyl)-;1-Methyl-1-acetyl-cyclohexan;methyl methylcyclohexyl ketone;1-Acetyl-1-methylcyclohexane;

Chemical Property of 1-Acetyl-1-methylcyclohexane

Chemical Property:

• Refractive Index: 1.4543
• Boiling Point: 186.2°C (estimate)
• PSA: 17.07000
• Density: 0.9504
• LogP: 2.54580

Purity/Quality:

95% ^*data from raw suppliers

1-(1-Methylcyclohexyl)ethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Acetyl-1-methylcyclohexane

There total 27 articles about 1-Acetyl-1-methylcyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1-methyl-1-cyclohexanecarboxylic acid (1123-25-7) + methyllithium (917-54-4) → methyl 1-methylcyclohexyl ketone (2890-62-2)

Guidance literature:

In diethyl ether; at 0 - 25 ℃; for 4.5h;

DOI:10.1002/chem.200400723

Reference yield: 59.0%

phenylacetic acid (103-82-2) + methyllithium (917-54-4) → methyl 1-methylcyclohexyl ketone (2890-62-2)

Guidance literature:

phenylacetic acid; methyllithium; In diethyl ether; at 0 - 20 ℃; for 4.5h; Inert atmosphere;

With hydrogenchloride; In diethyl ether; water; Inert atmosphere; Cooling with ice;

DOI:10.1246/cl.2012.780

Reference yield: 51.0%

2-(1-Hydroxy-spiro[2.5]oct-1-yl)-malonic acid diethyl ester (77320-49-1) → methyl 1-methylcyclohexyl ketone (2890-62-2)

Guidance literature:

With sodium hydroxide; for 24h; Ambient temperature;

DOI:10.1021/jo00327a017

upstream raw materials:

1-(1-methylcyclohexyl)ethan-1-ol

(1-methylcyclohex-4-en-1-yl)-methyl-keton

2-(1-hydroxycyclohexyl)propan-2-ol

dimethylcadmium

Downstream raw materials:

2-(1-methyl-cyclohexyl)-propan-2-ol

1-ethynyl-1-methylcyclohexane

1-methyl-1-cyclohexanecarboxylic acid

1-Methylcyclohexylmethylketoxim-pikrat

Refernces

• 1、 Fotiou, Theodora,Triantis, Theodoros M.,Kaloudis, Triantafyllos,Papaconstantinou, Elias,Hiskia, Anastasia. "Photocatalytic degradation of water taste and odour compounds in the presence of polyoxometalates and TiO2: Intermediates and degradation pathways". . p. 1 - 9. Retrieved 2014/05/20.
• 2、 Stulgies, Balder,Prinz, Peter,Magull, Joerg,Rauch, Karsten,Meindl, Kathrin,Ruehl, Stephan,De Meijere, Armin. "Six- and eightfold palladium-catalyzed gross-coupling reactions of hexa- and octabromoarenes". . p. 308 - 320. Retrieved 2007/10/03.