- Proflavine
- Proflavine monohydrochloride
- Proflavine sulfate
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Cas Database |
| Name |
Proflavine monohydrochloride |
EINECS | 213-459-9 |
| CAS No. | 952-23-8 | Density | 1.346g/cm3 |
| PSA | 64.93000 | LogP | 4.51680 |
| Solubility | N/A | Melting Point |
270°C (dec.) (lit.) |
| Formula | C13H11 N3 . Cl H | Boiling Point | 506.9°Cat760mmHg |
| Molecular Weight | 245.711 | Flash Point | 292.9°C |
| Transport Information | N/A | Appearance | N/A |
| Safety | Poison by subcutaneous route. Questionable carcinogen. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and HCl. Used as a drug, as a disinfectant, and as a topical antiseptic. | Risk Codes | N/A |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
3,6-Acridinediamine,monohydrochloride (9CI); Acridine, 3,6-diamino-, monohydrochloride (8CI);3,6-Diaminoacridine monohydrochloride; 3,6-Diaminoacridinium chloride; NSC605756; Proflavine hydrochloride; Proflavine monohydrochloride |
Article Data | 2 |
Proflavine monohydrochloride Chemical Properties
IUPAC Name: (6-Aminoacridin-3-yl)azanium chloride
Synonyms: 3,6-Acridinediamine hydrochloride ; 3,6-Acridinediamine hydrochloride (1:1) ; 3,6-Acridinediamine, hydrochloride (1:1) ; 3,6-Acridinediamine, hydrochloride (8CI)
CAS NO: 952-23-8
Molecular Formula of Proflavine monohydrochloride (CAS NO.952-23-8) : C13H12ClN3
Molecular Weight of Proflavine monohydrochloride (CAS NO.952-23-8) : 245.71
Molecular Structure of Proflavine monohydrochloride (CAS NO.952-23-8) : 
EINECS: 213-459-9
Flash Point: 292.9 °C
Enthalpy of Vaporization: 77.69 kJ/mol
Boiling Point: 506.9 °C at 760 mmHg
Vapour Pressure: 2.14E-10 mmHg at 25
Appearance:Brown powder.
Water solubility:Slightly soluble in water.
Proflavine monohydrochloride Toxicity Data With Reference
| 1. | mmo-sat 300 ng/plate | IAPUDO IARC Publications. 27 (1980),283. | ||
| 2. | mma-sat 3 µg/plate | IAPUDO IARC Publications. 27 (1980),283. | ||
| 3. | mma-esc 10 µg/plate | ENMUDM Environmental Mutagenesis. 7 (Suppl 5)(1985),1. | ||
| 4. | orl-rat TDLo:27 g/kg/109W-C:ETA | NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-TR-5 ,1977. | ||
| 5. | scu-mus LD50:190 mg/kg | QJPPAL Quarterly Journal of Pharmacy and Pharmacology. 10 (1937),649. |
Proflavine monohydrochloride Consensus Reports
IARC Cancer Review: Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 24 ,1980,p. 195.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 24 ,1980,p. 195.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . NTP Carcinogenesis Bioassay (feed); Clear Evidence: rat NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-TR-5 ,1977. ; (feed); Inadequate Studies: mouse NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-TR-5 ,1977. .
Proflavine monohydrochloride Safety Profile
Poison by subcutaneous route. Questionable carcinogen. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and HCl. Used as a drug, as a disinfectant, and as a topical antiseptic.
Proflavine monohydrochloride Specification
Reactivity Profile: 3,6-Diaminoacridine hydrochloride is amphoteric. Reacts both as a weak acid and as a weak base.
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