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Sodium 4-aminosalicylate
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Name

Sodium 4-aminosalicylate

 EINECS 205-091-2
CAS No. 133-10-8 Density 1.491g/cm3
PSA 86.38000 LogP -0.08090
Solubility N/A Melting Point 150-151oC, with effervescence
Formula C7H6NNaO3 Boiling Point 380.8 °C at 760 mmHg
Molecular Weight 175.119 Flash Point 184.1 °C
Transport Information N/A Appearance white crystalline
Safety 26-36 Risk Codes 36/37/38
Molecular Structure Molecular Structure of 133-10-8 (Sodium 4-aminosalicylate) Hazard Symbols IrritantXi
Synonyms

Tubersan;p-Aminosalicylate sodium;p-Aminosalicylic acidsodium salt;Benzoicacid, 4-amino-2-hydroxy-, monosodium salt (9CI);Salicylic acid, 4-amino-,monosodium salt (8CI);4-Aminosalicylic acid sodium salt;Bactylan;Natri-Pas;Nippas;Pasade;Pasalon-Rakeet;Pasnal;Passodico;Salvis;Sanipirol;Sodiopas;Sodium 2-hydroxy-4-aminobenzoate;Sodium 4-amino-2-hydroxybenzoate;Sodium PAS;Sodiump-aminosalicylate;

Article Data 3

Sodium 4-aminosalicylate Synthetic route

65-49-6

4-Aminosalicylic acid

133-10-8

sodium p-aminosalicylate

Conditions
ConditionsYield
With sodium carbonate
With sodium hydroxide In water at 20℃;
65944-71-0

cytosinium 4-aminosalicylate

133-10-8

sodium p-aminosalicylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: ethanol / Milling
2: sodium hydroxide / water / 20 °C
View Scheme
108-77-0

1,3,5-trichloro-2,4,6-triazine

7336-20-1

disodium salt of 4,4'-diaminostilbene-2,2'-disulfonic acid

133-10-8

sodium p-aminosalicylate

74-89-5

methylamine

C36H28N12O12S2(4-)*4Na(1+)

Conditions
ConditionsYield
Stage #1: 1,3,5-trichloro-2,4,6-triazine; disodium salt of 4,4'-diaminostilbene-2,2'-disulfonic acid
Stage #2: sodium p-aminosalicylate
Stage #3: methylamine		98%
22509-74-6

N-ethoxycarbonylphthalimide

133-10-8

sodium p-aminosalicylate

36467-52-4

2-hydroxy-4-(1,3-dioxoisoindolin-2-yl)benzoic acid

Conditions
ConditionsYield
With sodium hydrogencarbonate; triethylamine In water at 5℃; for 5h;95.1%

copper(II) chloride monohydrate

133-10-8

sodium p-aminosalicylate

1277176-65-4

[Cu2(p-aminosalicylato)4(H2O)2]

Conditions
ConditionsYield
In ethanol reacted for 0.5 h; H2O added slowly, filtered, rinsed with H2O and cold EtOH; elem. anal.;88%
23911-26-4

diethylenetriaminepentaacetic dianhydride

133-10-8

sodium p-aminosalicylate

C28H28N5O14(5-)*5Na(1+)

Conditions
ConditionsYield
In dimethyl sulfoxide at 20℃; for 2h;85%
In dimethyl sulfoxide for 1.5h; Ambient temperature;55%
108-24-7

acetic anhydride

133-10-8

sodium p-aminosalicylate

50-86-2

4-acetamidosalicylic acid

Conditions
ConditionsYield
In water at 45℃; for 4h;84.12%

copper(II) chloride monohydrate

133-10-8

sodium p-aminosalicylate

109-76-2

Trimethylenediamine

1277176-70-1

[Cu(p-aminosalicylato)2(1,3-propanediamine)2]

Conditions
ConditionsYield
In ethanol a soln. of Cu salt added to a soln. of Na salt, CH2(CH2NH2)2 added after0.5 h; H2O added slowly, filtered, rinsed with H2O and cold EtOH; elem. anal.;84%
133-10-8

sodium p-aminosalicylate

20949-66-0

2-methylsulfanyl-thiazol-4-one

81059-99-6

2-(4-carboxy-3-hydroxyphenyl)amino-Δ2-thiazolin-4-one

Conditions
ConditionsYield
In ethanol for 1.5h; Heating;80%
23911-25-3

ethylenediaminetetraacetic dianhydride

133-10-8

sodium p-aminosalicylate

C24H24N4O12(2-)*2Na(1+)

Conditions
ConditionsYield
With magnesium sulfate In dimethyl sulfoxide at 70℃; for 18h; Inert atmosphere;80%

Sodium 4-aminosalicylate Chemical Properties

Product Name:  Sodium 4-aminosalicylate 
Synonyms:  4-Amino-salicylic acid sodium salt
Molecular Structure of Sodium p-aminosalicylate (133-10-8) :  
Molecular Formula : C7H6NNaO3
Molecular Weight:  175.12
CAS  :133-10-8
EINECS:  205-091-2

Sodium 4-aminosalicylate Uses

1.Sodium p-aminosalicylate (133-10-8) is used as a disincentive to inhibit growth of Mycobacterium tuberculosis of the amino acid synthesis
2.This product is rarely alone used, often associated with isoniazid, streptomycin and other applications . enhance efficacy and to avoid bacterial resistance.
3.Can also be used for hyperthyroidism. good for hyperthyroidism TB patients, are more applicable in using iodine invalid during the operation, it can create the conditions for surgery when take it short-term
4.Sodium p-aminosalicylate (133-10-8) still has a strong effect on lipid-lowering .

Sodium 4-aminosalicylate Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 3850mg/kg (3850mg/kg)   Dissertationes Pharmaceuticae et Pharmacologicae. Vol. 23, Pg. 383, 1971.
mouse LD50 intravenous 3380mg/kg (3380mg/kg)   Yaoxue Tongbao. Bulletin of Pharmacology. Vol. 15(12), Pg. 17, 1980.
mouse LD50 oral 6900mg/kg (6900mg/kg)   Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, Biochemie, Biophysik, Biologie. Vol. 6B, Pg. 183, 1951.
mouse LD50 subcutaneous 2800mg/kg (2800mg/kg)   Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 146, Pg. 466, 1952.
rat LD50 intraperitoneal 4950mg/kg (4950mg/kg)   Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, Biochemie, Biophysik, Biologie. Vol. 6B, Pg. 183, 1951.
rat LD50 oral 8gm/kg (8000mg/kg)   Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, Biochemie, Biophysik, Biologie. Vol. 6B, Pg. 183, 1951.
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