Welcome to LookChem.com Sign In|Join Free
  • or
Home > Products >  > 

Sulbactam

Related Products

Hot Products

Name

Sulbactam

EINECS 269-878-2
CAS No. 68373-14-8 Density 1.62 g/cm3
PSA 100.13000 LogP 0.22370
Solubility Soluble in water at 18mg/ml Melting Point 146-151oC
Formula C8H11NO5S Boiling Point 567.7 °C at 760 mmHg
Molecular Weight 233.245 Flash Point 297.1 °C
Transport Information N/A Appearance white to off-white crystalline powder
Safety 24/25 Risk Codes 22
Molecular Structure Molecular Structure of 68373-14-8 (Sulbactam) Hazard Symbols Xn
Synonyms

4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 3,3-dimethyl-7-oxo-, 4,4-dioxide, (2S-cis)-;Betamaze;CP 45899;Penicillanic acid 1,1-dioxide;Penicillanic acid S,S-dioxide;Penicillanic aciddioxide;Penicillanic acid sulfone;Sulbactam;Piperacillin Sodium and Sulbactam Sodium (1:8);Sulbactam Acid;

Article Data 29

Sulbactam Synthetic route

(2S,5R)-3,3-Dimethyl-4,4,7-trioxo-4λ6-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 2-chloro-allyl ester

68373-14-8

sulbactum

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); sodium 4-methylbenzenesulfinate In tetrahydrofuran; methanol for 1h; Ambient temperature;99%
76646-91-8

6,6-dibromopenicillanic acid-1,1-dioxide

68373-14-8

sulbactum

Conditions
ConditionsYield
With sulfuric acid; zinc In water at 12℃; for 2h; Temperature; Large scale;96%
With hydrogenchloride; magnesium In dichloromethane; water at -5 - 3℃; for 0.5h; Reagent/catalyst; Solvent; Temperature;93.1%
With tri-n-butyl-tin hydride In ethyl acetate at 20℃; for 2h; Temperature; Time; Inert atmosphere;90.9%
69388-78-9

(2S,5R)-Benzyl 3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate 4,4-Dioxide

68373-14-8

sulbactum

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In ethyl acetate for 1h; Ambient temperature;96%
Conditions
ConditionsYield
Stage #1: 6-aminopenicillanic acid With sulfuric acid; hypophosphorous acid; sodium nitrite In water; ethyl acetate at -10℃; for 1.5h;
Stage #2: With sodium tungstate (VI) dihydrate; dihydrogen peroxide In water at -5℃; for 1h; Temperature;
94.9%
69388-84-7

sodium sulbactam

68373-14-8

sulbactum

Conditions
ConditionsYield
With tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide In dichloromethane; water at 20℃; for 0.166667h; pH=6.9 - 7;94.8%
With hydrogenchloride In water; ethyl acetate87.2%
Multi-step reaction with 2 steps
1: 86 percent / hexamethylphosphoric acid triamide / 18 h / 55 °C
2: 99 percent / sodium p-toluenesulfinate tetrahydrate, Pd(PPh3)4 / methanol; tetrahydrofuran / 1 h / Ambient temperature
View Scheme
76646-91-8

6,6-dibromopenicillanic acid-1,1-dioxide

7440-02-0

nickel

68373-14-8

sulbactum

Conditions
ConditionsYield
With copper In dichloromethane; water; acetic acid; acetonitrile84%
7439-96-5

manganese

810692-15-0

6-bromo-1,1-dioxopenicillanic acid

68373-14-8

sulbactum

Conditions
ConditionsYield
With phosphoric acid; iron In acetic acid methyl ester; water80%

sodium salt of penicillanic acid

68373-14-8

sulbactum

Conditions
ConditionsYield
With potassium permanganate; sodium chloride; sodium hydrogensulfite In water78%
85871-31-4

(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl penicillanate 1,1-dioxide

68373-14-8

sulbactum

Conditions
ConditionsYield
With sodium hydrogencarbonate In water; acetone at 5 - 10℃; for 4h; pH 9;65%
87-53-6

penicillanic acid

68373-14-8

sulbactum

Conditions
ConditionsYield
With hydrogenchloride; sodium hydroxide; potassium permanganate; sodium hydrogensulfite In water; acetic acid; ethyl acetate26%
With potassium permanganate; phosphoric acid; sodium hydroxide In water at 0 - 5℃; for 2h; pH=7.5; Temperature; pH-value;49.5 g

Sulbactam Specification

The Sulbactam , with cas registry number of 68373-14-8, is a kind of Peptide Synthesis/Antibiotics; Anti-Bacterial Agents; Anti-Infective Agents; Enzyme inhibitors. It is also called Sulbactam acid (base) . The IUPAC name is (2S,5R)-3,3-dimethyl-4,4,7-trioxo-4$l^{6}-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid . And the systematic name is called (2S,5R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide . It should be stored at temperature of -20°C.

Physical properties of Sulbactam are: (1) ACD/LogP: -1.39 ; (2) # of Rule of 5 Violations: 0 ; (3) ACD/LogD (pH 5.5): -4.31 ; (4) ACD/LogD (pH 7.4): -5.11 ; (5) ACD/BCF (pH 5.5): 1 ; (6) ACD/BCF (pH 7.4): 1 ; (7) ACD/KOC (pH 5.5): 1 ; (8) ACD/KOC (pH 7.4): 1 ; (9) #H bond acceptors: 6 ; (10) #H bond donors: 1 ; (11) #Freely Rotating Bonds: 1 ; (12) Index of Refraction: 1.605 ; (13) Molar Refractivity: 49.42 cm3 ; (14) Molar Volume: 143.4 cm3 ; (15) Surface Tension: 71.3 dyne/cm ; (16) Enthalpy of Vaporization: 93.14 kJ/mol ; (17) Vapour Pressure: 2.26E-14 mmHg at 25°C.

Uses of Sulbactam : This compound is a irreversible inhibitor of beta-lactamase which is given in combination with beta-lactam antibiotics to inhibit beta-lactamase, an enzyme produced by bacteria that destroys the antibiotics.

You can still convert the following datas into molecular structure:
(1) SMILES:O=S2(=O)C([C@@H](N1C(=O)C[C@H]12)C(=O)O)(C)C;
(2) InChI:InChI=1/C8H11NO5S/c1-8(2)6(7(11)12)9-4(10)3-5(9)15(8,13)14/h5-6H,3H2,1-2H3,(H,11,12)/t5-,6+/m1/s1;
(3) InChIKey:FKENQMMABCRJMK-RITPCOANBJ

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 68373-14-8