Basic Information | Post buying leads | Suppliers | Cas Database |
Name |
TEMAZEPAM |
EINECS | N/A |
CAS No. | 846-50-4 | Density | 1.34g/cm3 |
PSA | 52.90000 | LogP | 1.97280 |
Solubility | N/A | Melting Point |
119-121°C |
Formula | C16H13 Cl N2 O2 | Boiling Point | 549.9oC at 760 mmHg |
Molecular Weight | 300.744 | Flash Point | 11oC |
Transport Information | N/A | Appearance | N/A |
Safety | Poison by ingestion and intraperitoneal routes. Human systemic effects by ingestion: muscle weakness and changes in the structure or function of the salivary glands. A tranquilizer. When heated to decomposition it emits toxic fumes of Cl− and NOx. See also DIAZEPAM. | Risk Codes | 22-39/23/24/25-23/24/25-11 |
Molecular Structure | Hazard Symbols | Xn,T,F | |
Synonyms |
(RS)-Temazepam;(?à)-Temazepam;1-Methyl-3-hydroxy-5-phenyl-7-chloro-1,3-dihydro-2H-1,4-benzodiazepin-2-one;3-Hydroxydiazepam;7-Chloro-1,3-dihydro-1-methyl-3-hydroxy-5-phenyl-2H-1,4-benzodiazepin-2-one;7-Chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one;7-Chloro-1,3-dihydro-5-phenyl-3-hydroxy-1-methyl-2H-1,4-benzodiazepin-2-one;7-Chloro-3-hydroxy-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepine; Crisonar; ER115; Euhypnos; Euipnos; Gelthix; K 3917; Levanxene; Levanxol; Methyloxazepam;N-Methyloxazepam; NSC 246303; Normison; Oxydiazepam; Perdorm; Planum; Racemictemazepam; Remestan; Restoril; Ro 5-5345; Ro 5-5354; Signopam; Temazepam;Tenox; Tenox (pharmaceutical); Wy 3917 |
Article Data | 22 |
Product Name: Temazepam (CAS NO.846-50-4)
Molecular Formula: C16H13ClN2O2
Molecular Weight: 300.74g/mol
Mol File: 846-50-4.mol
Einecs: 212-688-1
Appearance: Crystalline Solid
Melting Point: 119-121°C
Boiling point: 549.9 °C at 760 mmHg
Storage Temperature: 2-8°C
Flash Point: 286.4 °C
Density: 1.34 g/cm3
Surface Tension: 50.2 dyne/cm
Enthalpy of Vaporization: 87.32 kJ/mol
Vapour Pressure: 6.33E-13 mmHg at 25°C
XLogP3: 2.2
H-Bond Donor: 1
H-Bond Acceptor: 3
Product Categories: Heterocycles; Intermediates and Fine Chemicals; Metabolites and Impurities; Pharmaceuticals; Isotope Labeled Compounds
Temazepam (CAS NO.846-50-4) was first synthesized in 1964, but it first came into use in 1969 when its ability to counter insomnia was realized.[5] By the late 1980s, temazepam was one of the most popular and widely prescribed hypnotics on the market and it became one of the most widely prescribed drugs.
Temazepam is a hypnotic agent. In sleep laboratory studies, temazepam significantly decreased the number of nightly awakenings but has the drawback of distorting the normal sleep pattern.
Temazepam is officially indicated for severe insomnia and other severe or disabling sleep disorders. The prescribing guidelines limit prescribing of hypnotics to two-to-four weeks due to concerns of tolerance and dependence.
The United States Air Force uses temazepam as one of the hypnotics approved as "no-go pills" to help aviators and special duty personnel sleep in support of mission readiness. "Ground tests" are required prior to authorization being issued to use the medication in an operational situation.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LD50 | oral | 3620mg/kg (3620mg/kg) | Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. Vol. 21, Pg. 321, 1981. | |
human | TDLo | oral | 600ug/kg (0.6mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Human Psychopharmacology. Vol. 10, Pg. 449, 1995. |
human | TDLo | oral | 15430ug/kg/12 (15.43mg/kg) | BEHAVIORAL: MUSCLE WEAKNESS GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS | Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 93, 1972. |
man | TDLo | oral | 429ug/kg (0.429mg/kg) | BEHAVIORAL: EXCITEMENT BEHAVIORAL: REGIDITY | Journal of Clinical Psychiatry. Vol. 46, Pg. 280, 1985. |
mouse | LD50 | intraperitoneal | 85mg/kg (85mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 185, Pg. 135, 1970. | |
mouse | LD50 | oral | 370mg/kg (370mg/kg) | BEHAVIORAL: ANTICONVULSANT | European Journal of Pharmacology. Vol. 4, Pg. 467, 1968. |
rat | LD50 | intraperitoneal | 600mg/kg (600mg/kg) | Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. Vol. 21, Pg. 321, 1981. | |
rat | LD50 | oral | 2gm/kg (2000mg/kg) | Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. Vol. 21, Pg. 321, 1981. | |
women | TDLo | oral | 600ug/kg (0.6mg/kg) | BEHAVIORAL: EXCITEMENT | Journal of Clinical Psychiatry. Vol. 46, Pg. 280, 1985. |
Poison by ingestion and intraperitoneal routes. Human systemic effects by ingestion: muscle weakness and changes in the structure or function of the salivary glands. A tranquilizer. When heated to decomposition it emits toxic fumes of Cl− and NOx. See also DIAZEPAM.
Safety Information of Temazepam (CAS NO.846-50-4):
Hazard Codes: Xn,T,F
Risk Statements: 22-39/23/24/25-23/24/25-11
11: Highly Flammable
22: Harmful if swallowed
23: Toxic by inhalation
24: Toxic in contact with skin
25: Toxic if swallowed
39: Danger of very serious irreversible effects
Safety Statements: 16-36/37-45
16: Keep away from sources of ignition - No smoking
36: Wear suitable protective clothing
37: Wear suitable gloves
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
Temazepam ,its CAS NO. is 846-50-4,the synonyms is 1,3-Dihydro-7-chloro-3-hydroxy-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one ; 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-3-hydroxy-1-methyl-5-phenyl- ; 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl- ; 3-Hydroxydiazepam ; 7-Chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one ; 7-Chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl-2h-4-benzodiazepin-2-one ; 7-Chloro-3-hydroxy-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one