Product Name: Tripelennamine (CAS NO.91-81-6)

Molecular Formula: C₁₆H₂₁N₃
Molecular Weight: 255.40g/mol
Mol File: 91-81-6.mol
Einecs: 202-100-1
Appearance: Oily liquid with an amine odor
Storage Temperature: 387.8 °C at 760 mmHg
Flash Point: 188.3 °C
Stability: Stable. Incompatible with strong oxidizing agents
Surface Tension: 46.1 dyne/cm
Enthalpy of Vaporization: 63.69 kJ/mol
Vapour Pressure: 3.21E-06 mmHg at 25°C
XLogP3-AA: 3.3
H-Bond Donor: 0
H-Bond Acceptor: 3

 Tripelennamine (CAS NO.91-81-6) was first synthesized by Carl Djerassi, working in the laboratory of Charles Huttrer at Ciba, shortly after Djerassi got his B.S. It was his first patent.

 Tripelennamine (CAS NO.91-81-6) is sometimes abused recreationally in combination with the synthetic opioid pentazocine ,or morphine , by preparing an injection containing both agents; tripelennamine is also used with cough syrups and analgesic solid preparations containing opioids including codeine, propoxyphene, dextropropoxyphene, hydrocodone, ethylmorphine , paregoric, benzylmorphine, tramadol ,oxycodone ,and dihydrocodeine and its derivatives. hydromorphone ,oxymorphone ,and solid forms of methadone by either method.
It is dangerous to combine an opiate with a sedating antihistamine via injection, although the use of antihistamines to reduce opioid requirements for pain relief is a well-known practice, which is done under medical supervision with tripelennamine, as well as hydroxyzine, cyclizine, promethazine, diphenhydramine, phenindamine, orphenadrine, meclizine, chlorpheniramine, cyproheptadine and others; this method is doubly useful when used with opioids which release a great deal of histamine when administered and therefore cause itching, redness of skin and other histamine-related effects.
Like many of the first-generation antihistamines of the ethanolamine and alkylamine classes, tripelennamine and other members of its chemical class  produces a marginal to moderate euphoria; triepelennamine has a euphoriant effect with a relatively rapid onset and up to eight hours in duration. The ethylenediamine antihistamines rank between the ethanolamines and the alkylamines in this effect—somewhat weaker than orphenadrine and phenyltoloxamine, a bit stronger than brompheniramine and roughly comparable to dexchlorpheniramine and triprolidine.

Poison by ingestion and intraperitoneal routes. Human mutation data reported. Has been implicated in aplastic anemia. Used as an antihistamine. Addicts have added it to paregoric to make “blue velvet,” which can cause euphoria by injection. When heated to decomposition it emits toxic fumes of NO_x.

 Tripelennamine ,its CAS NO. is 91-81-6,the synonyms is Tripelennamine ;1,2-Ethanediamine, N,N-dimethyl-N-(phenylmethyl)-N-2-pyridinyl- ; Pyribenzamine ; Benzoxale ; N,N-Dimethyl-N'-(phenylmethyl)-N'-(2-pyridinyl)-1,2-ethanediamine ; Resistamine ; Tonaril ; Tripelenamine .