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Chemical Baike

Aza-Michael Addition

The Michael addition is a well-known reaction in organic chemistry where a nucleophile (a species with a pair of electrons to donate) adds to a π-unsaturated system, often an α,β-unsaturated carbonyl compound. When this reaction involves a nitrogen atom (aza-Michael), it typically results in the formation of a new carbon-nitrogen bond. In this context, the intramolecular aza-Michael addition means that the reaction takes place within the same molecule.

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