Start by designing the molecule you want to synthesize. In this case, you want to create P2 cyclopentene- and cyclohexenedicarboxylic acid derivatives that are capable of inhibiting thrombin. Determine the appropriate functional groups and structural features needed for binding to the thrombin active site.
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cyclohex-2-ene-1,2-dicarboxylic acid 1-methyl ester
Ethyl acetate
Anisole
