The term "discovery" in this context refers to the identification and development of these dihydropyrazino-benzimidazole derivatives as PAMs for mGluR2. This process typically involves extensive research, chemical synthesis, and testing to assess the compounds' efficacy, safety, and potential therapeutic applications.
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1-Benzimidazoleethanol,2-(hydroxymethyl)-(6CI)
2-(5-Bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene
(2R,4S,7S,14E)-7-cyclohexyl-23-methoxy-4-(methoxycarbonyl)-6-oxo-20-phenyl-3,4,6,7,8,9,10,11,12,13-decahydro-2H-16,18-etheno-2,5-methanopyrido[3,4-r][1,5,8]oxadiazacyclononadecin-8-ium trifluoroacetate
Ethanone, 1-(5,5-dimethyl-1-cyclohexen-1-yl)-
phenyl 3,4,6-tri-O-acetyl-2-deoxy-1-thio-2-(2,2,2-trichloroethoxycarbonylamino)-β-D-glucopyranoside S-oxide
1-Bromo-4-(bromomethyl)-2-methoxybenzene
2-(2-bromo-4-isopropylphenoxy)-N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide
5-(4-FLUOROPHENYL)FURAN-2-CARBONYL CHLORIDE
Benzene, 1-[(methylsulfonyl)methyl]-3-nitro-
5-(4-methoxyphenyl)-5-methyl-3-(4-(2-oxo-8-n-propyl-4-(trifluoromethyl)-2H-chromen-7-yloxy)butyl)imidazolidine-2,4-dione
[4-((R)-sec-Butoxy)-3-methoxy-phenyl]-acetic acid
(2R,3S)-3-amino-1-((3-(tert-butyl)benzyl)amino)-4-phenylbutan-2-ol
(2,5-diaminophenyl)-phosphonic acid diethyl ester
4-(4-{4-[(2-phenyl-5-trifluoromethyloxazole-4-carbonyl)amino]phenyl}piperazine-1-carbonyl)-trans-cyclohexanecarboxylic acid
methyl 2-bromo-4,5-dimethylthiophene-3-carboxylate
tert-butyldiphenylsilyl 3β-hydroxylup-20(29)-en-28-oate
[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-[2-(1H-indol-3-yl)-ethyl]-amine
3-chloromethyl-benzoic acid allyl ester
[4-(morpholin-4-yl)-phenyl]-(7-phenyl-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-amine
N-[2-(4-chlorophenyl)ethyl]-1-amino-2-methylpropanol
N-(4-(2-cyanopropan-2-yl)-2-nitrophenyl)acetamide
methyl 2-(5-bromo-2-(tert-butyldimethylsilyloxy)phenyl)-3-(4-fluorophenyl)-3-oxopropanoate
perilloside A
Propanedinitrile, [[(2-methoxyphenyl)amino](methylthio)methylene]-
C29H34FN3O2
C20H19ClF2O5S
S-ethyl 3-[4-(3,5-dichloropyrid-4-ylcarboxamido)-phenyl]-2-(4-methoxy-6-dimethylamino-1,3,5-triazin-2-ylamino)propionate
2-nitro-5-thiomorpholinophenol
Benzenamine, 2-[2-[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-2 H-tetrazol-5-yl]-4,5-dimethoxy-
1-(4-Methoxyphenyl)-6-(4-iodophenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester
N-(1-(3-aminophenyl)-1H-pyrrolo[3,2-c]pyridin-4-yl)benzamide
C28H26Cl6O5
3-Acetyl-N-[(phenylMethoxy)carbonyl]-O-(phenylMethyl)-L-tyrosine Methyl Ester
L-Proline, 1-[2-hydroxy-1-oxo-6-[[(phenylmethoxy)carbonyl]amino]hexyl]-, phenylmethyl ester, (S)-
5-CHLORO-2-IODOPYRIDINE
5-(2-chlorophenyl)-5-methylimidazolidine-2,4-dione
4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-N-(4-trifluoromethyl-pyridin-2-yl)benzamide
ethyl 5-(2,4-dihydroxy-5-isopropylphenyl)-3-(ethylcarbamoyl)-4,5'-biisoxazole-3'-carboxylate
3-(1,2,3,4-Tetrahydro-6-methoxy-1-oxo-2-naphthoyl)propionicacid
5-[[4-[N-(2,3-dimethyl-2H-indazol-6-yl)-N-methylamino]-6,7-dihydro-5H-cyclopenta[d]pyrimidin-2-yl]amino]-2-methyl-benzenesulfonamide
3-benzyl-1-(β-D-xylopyranosyl)-1H-indole
C28H31NO5
Benzeneacetonitrile, 4-chloro-a-(1H-pyrrol-2-ylmethylene)-, (Z)-
methyl 2-chloro-4-methyl-6-(m-tolylamino)pyrimidine-5-carboxylate
Benzene, 1-fluoro-4-[(1E)-2-isocyanatoethenyl]- (9CI)
o-chlorophenyl isoselenocyanate
2-(3-(4-fluorophenyl)-5-(furan-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)-4-phenylthiazole
C18H14FN3O3
4-(4-aminophenoxy)quinolin-2(1H)-one
MK 0974, Telcagepant
