This implies that the compounds in this series have a high affinity for their target, which is the γ-secretase enzyme. This high potency suggests that even at lower concentrations, these compounds can effectively inhibit the activity of γ-secretase.
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C17H21N3O2
1,3-Benzenediamine, N-[4-(3-pyridinyl)-2-pyrimidinyl]-
[(2R,3S,4S,5R,6R)-3,5-Bis-benzyloxy-2-benzyloxymethyl-6-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-4-yloxy]-(dimethoxy-phosphoryl)-acetic acid methyl ester
Oxirane, [[4-(phenylmethoxy)phenoxy]methyl]-, (2S)-
N-BOC-3,4-Dihydro-2(1H)-quinolinone
7α-(4-nitrophenyl)-endo-6α,14α-vinyltetrahydrothebaine
5-Pyrimidinecarboxylic acid, 1,4-dihydro-2-[[(4-methoxyphenyl)methyl]thio]-6-methyl-4-(3-nitrophenyl) -, 1-methylethyl ester, (R)-
1-Bromo-4-(bromomethyl)-2-methoxybenzene
5-(4-FLUOROPHENYL)FURAN-2-CARBONYL CHLORIDE
Benzene, 1-[(methylsulfonyl)methyl]-3-nitro-
(+/-)-trans-1,2-Cyclopropanedicarboxylic acid
L-Phenylalanine, N-[(phenylmethoxy)carbonyl]-, hydrazide
C48H56N14O10
5-<(cyclopropylmethoxy)carbonyl>-3-<(heptyloxy)carbonyl>-1-N-(methoxymethyl)-6-methyl-4-(2-nitrophenyl)dihydropyrimidin-2-one
5-(1H-indol-3-yl)-3-(4-methylphenyl)-4,5-dihydroisoxazoline
2,3-diphenylimidazo[1,2-a]pyrimidine
(S)-3-(3-Cyano-phenyl)-2-(2,2,5,7,8-pentamethyl-chroman-6-sulfonylamino)-propionic acid
1,8-Naphthyridine-3-carboxamide, N-butyl-1,2-dihydro-4-hydroxy-2-oxo-1-phenyl-
2-Pentenoic acid, 5-[1-(triphenylmethyl)-1H-imidazol-4-yl]-, ethyl ester
C26H29F6N3O2
3-chloromethyl-benzoic acid allyl ester
C35H49N5O11
[4-(1-butyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxy]-acetic acid
tert-butyl (3-methylisoxazol-4-yl)carbamate
methyl trans-4-[1-benzyloxycarbonyl-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate
tert-butyl 2-{2,4-dioxo-5-[4-(4-oxo-1-piperidinyl)benzyl]-1,3-thiazolidin-3-yl}acetate
2-butyl-1-<(3'-carbomethoxybiphenyl-4-yl)methyl>-4-chloro-5-(hydroxymethyl)imidazole
C29H38O5
3-(2-chloro-4-methyl-phenyl)-propionic acid
bis(4-benzyl-1-piperidinylthiocarbonyl)disulfide
t-butyl 3-bromo-4-[[(2-phenylethyl)amino]methyl]-benzoate
1-benzyl-3-(phthalimidopropyl)-1H,3H-pyrido[2,1-f]purine-2,4-dione
4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid
C14H16N2O
Piperazine, 1-(2-methoxy-5-nitrophenyl)-4-methyl-
ethyl 9-methyl-1-phenyl-9H-pyrido[3,4-b]indole-3-carboxylate
RO-31-8425
1-Naphthaleneacetonitrile, a-[[[3-(trifluoromethyl)phenyl]methyl]amino]-
1-(biphenyl-4-yl)cyclopropanecarboxylic acid
N-{(2R,4S,5S)-2-benzyl-5-[(tert-butoxycarbonyl)amino]-4-hydroxy-6-phenylhexanoyl}-L-leucyl-L-phenylalaninamide
(S)-1-(2'-amino-2'-carboxyethyl)-3-benzylquinazoline-2,4(1H,3H)-dione
1(2H)-Isoquinolinone, 3-(aminomethyl)-6-bromo-2-(2-methylpropyl)-4-phenyl-
Boc-Trp-Nle-(N-Me)Asp(OBn)-Phe-NH2
2-(methylsulfanyl)-1,5,6,7-tetrahydro-4H-cyclopenta[d]pyrimidin-4-one
4-(2,6-dibromopyridine-4-sulphonyl)-phenylamine
2,6-diisopropyl-4-bromobenzaldehyde
1H-Pyrazole-3-carboxylic acid, 5-(4-chlorophenyl)-1-phenyl-
C20H19ClF2O5S
