Welcome to LookChem.com Sign In|Join Free
  • or
Home > Products >  > 

Tormosyl

Related Products

Hot Products

Name

Tormosyl

EINECS N/A
CAS No. 40507-23-1 Density 1.18g/cm3
PSA 34.89000 LogP 4.09190
Solubility N/A Melting Point 172-174°
Formula C18H17FN2O Boiling Point 436.6°C at 760 mmHg
Molecular Weight 296.344 Flash Point 217.9°C
Transport Information N/A Appearance N/A
Safety Moderately toxic by ingestion and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of F and NOx. Risk Codes N/A
Molecular Structure Molecular Structure of 40507-23-1 (Fluproquazone) Hazard Symbols N/A
Synonyms

RF 46-790;Fluproquazonum [INN-Latin];2(1H)-Quinazolinone,4-(p-fluorophenyl)-1-isopropyl-7-methyl;4-(4-fluoro-phenyl)-1-isopropyl-7-methyl-1H-quinazolin-2-one;fluproquazone;1-isopropyl-7-methyl-4-(p-fluorophenyl)-quinazolin-2(1H)-one;1-isopropyl-4-(4-fluorophenyl)-7-methyl-2(1H)-quinazolinone;SaH 46-790;Fluproquazona [INN-Spanish];1-Isopropyl-7-methyl-4-(p-fluorophenyl)-2(1H)-quinazolinone;4-(p-Fluorophenyl)-1-isopropyl-7-methyl-2(1H)-quinazolinone;Tormosyl;

Article Data 2

Tormosyl Chemical Properties

 Molecule structure of Tormosyl (CAS NO.40507-23-1) :

IUPAC Name: 4-(4-fluorophenyl)-7-methyl-1-propan-2-ylquinazolin-2-one 
Molecular Weight: 296.338783 g/mol
Molecular Formula: C18H17FN2
Density: 1.18 g/cm3 
Boiling Point: 436.6 °C at 760 mmHg
Flash Point: 217.9 °C
Index of Refraction: 1.596
Molar Refractivity: 85.03 cm3
Molar Volume: 249.8 cm3
Polarizability: 33.7×10-24 cm3
Surface Tension: 38.4 dyne/cm
Enthalpy of Vaporization: 69.31 kJ/mol 
Vapour Pressure: 7.98E-08 mmHg at 25 °C
XLogP3-AA: 4.1
H-Bond Acceptor: 2
Rotatable Bond Count: 2
Exact Mass: 296.132491
MonoIsotopic Mass: 296.132491
Topological Polar Surface Area: 32.7
Heavy Atom Count: 22
Complexity: 454
Canonical SMILES: CC1=CC2=C(C=C1)C(=NC(=O)N2C(C)C)C3=CC=C(C=C3)F
InChI: InChI=1S/C18H17FN2O/c1-11(2)21-16-10-12(3)4-9-15(16)17(20-18(21)22)13-5-7-14(19)8-6-13/h4-11H,1-3H3
InChIKey of Tormosyl (CAS NO.40507-23-1) : ZWOUXWWGKJBAHQ-UHFFFAOYSA-N

Tormosyl Uses

 Tormosyl (CAS NO.40507-23-1) is mainly used in the treatment of arthritis and post-operative pain.

Tormosyl Toxicity Data With Reference

1.    

orl-rat TDLo:500 mg/kg (female 6-15D post):TER

    ARZNAD    Arzneimittel-Forschung. Drug Research. 31 (1981),882.
2.    

ipr-mus LD50:650 mg/kg

    ARZNAD    Arzneimittel-Forschung. Drug Research. 34 (1984),879.
3.    

orl-rbt LD50:742 mg/kg

    ARZNAD    Arzneimittel-Forschung. Drug Research. 31 (1981),882.

Tormosyl Safety Profile

Moderately toxic by ingestion and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of F and NOx.

Tormosyl Specification

 Tormosyl (CAS NO.40507-23-1) is also called 1-Isopropyl-7-methyl-4-(p-fluorophenyl)-2(1H)-quinazolinone ; 4-(4-Fluorophenyl)-7-methyl-1-(1-methylethyl)-2(1H)-quinazolinone ; 4-(p-Fluorophenyl)-1-isopropyl-7-methyl-2(1H)-quinazolinone ; 4-Fluorphenyl-1-isopropyl-7-methyl-2(1H)-chinazolinon ; 4-Fluorphenyl-1-isopropyl-7-methyl-2(1H)-chinazolinon [German] ; 5-24-04-00375 (Beilstein Handbook Reference) ; BRN 0891838 ; Fluproquazona ; Fluproquazona [INN-Spanish] ; Fluproquazone ; Fluproquazonum ; Fluproquazonum [INN-Latin] ; RF 46-790 ; SaH 46-790 . Tormosyl (CAS NO.40507-23-1) is a quinazolinone derivative with potent analgesic and antipyretic effects and also anti-inflammatory action. It has been shown to be effective in a variety of animal species after both oral and parenteral administration, and has a duration of action of several hours. The compound is many times more potent than acetylsalicylic acid and clinically generally resembles ibuprofen and indoprofen in its pharmacological effects, but with significantly less ulcerogenic activity.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 40507-23-1