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40507-23-1

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Basic Information
CAS No.: 40507-23-1
Name: Fluproquazone
Article Data: 2
Molecular Structure:
Molecular Structure of 40507-23-1 (Fluproquazone)
Formula: C18H17FN2O
Molecular Weight: 296.344
Synonyms: RF 46-790;Fluproquazonum [INN-Latin];2(1H)-Quinazolinone,4-(p-fluorophenyl)-1-isopropyl-7-methyl;4-(4-fluoro-phenyl)-1-isopropyl-7-methyl-1H-quinazolin-2-one;fluproquazone;1-isopropyl-7-methyl-4-(p-fluorophenyl)-quinazolin-2(1H)-one;1-isopropyl-4-(4-fluorophenyl)-7-methyl-2(1H)-quinazolinone;SaH 46-790;Fluproquazona [INN-Spanish];1-Isopropyl-7-methyl-4-(p-fluorophenyl)-2(1H)-quinazolinone;4-(p-Fluorophenyl)-1-isopropyl-7-methyl-2(1H)-quinazolinone;Tormosyl;
Density: 1.18g/cm3
Melting Point: 172-174°
Boiling Point: 436.6°C at 760 mmHg
Flash Point: 217.9°C
Safety: Moderately toxic by ingestion and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of F− and NOx.
PSA: 34.89000
LogP: 4.09190
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    TORMOSYL

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    Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

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    TORMOSYL

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    hight degree of purity Application:Fine chemical intermediates, used as the main raw material for he synthesis of various pesticides, medicines, surfactants, polymer monomers, Ond Ontifungal agents

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Chemistry

 Molecule structure of Tormosyl (CAS NO.40507-23-1) :

IUPAC Name: 4-(4-fluorophenyl)-7-methyl-1-propan-2-ylquinazolin-2-one 
Molecular Weight: 296.338783 g/mol
Molecular Formula: C18H17FN2O 
Density: 1.18 g/cm3 
Boiling Point: 436.6 °C at 760 mmHg
Flash Point: 217.9 °C
Index of Refraction: 1.596
Molar Refractivity: 85.03 cm3
Molar Volume: 249.8 cm3
Polarizability: 33.7×10-24 cm3
Surface Tension: 38.4 dyne/cm
Enthalpy of Vaporization: 69.31 kJ/mol 
Vapour Pressure: 7.98E-08 mmHg at 25 °C
XLogP3-AA: 4.1
H-Bond Acceptor: 2
Rotatable Bond Count: 2
Exact Mass: 296.132491
MonoIsotopic Mass: 296.132491
Topological Polar Surface Area: 32.7
Heavy Atom Count: 22
Complexity: 454
Canonical SMILES: CC1=CC2=C(C=C1)C(=NC(=O)N2C(C)C)C3=CC=C(C=C3)F
InChI: InChI=1S/C18H17FN2O/c1-11(2)21-16-10-12(3)4-9-15(16)17(20-18(21)22)13-5-7-14(19)8-6-13/h4-11H,1-3H3
InChIKey of Tormosyl (CAS NO.40507-23-1) : ZWOUXWWGKJBAHQ-UHFFFAOYSA-N

Uses

 Tormosyl (CAS NO.40507-23-1) is mainly used in the treatment of arthritis and post-operative pain.

Toxicity Data With Reference

1.    

orl-rat TDLo:500 mg/kg (female 6-15D post):TER

     ARZNAD    Arzneimittel-Forschung. Drug Research. 31 (1981),882.
2.    

ipr-mus LD50:650 mg/kg

     ARZNAD    Arzneimittel-Forschung. Drug Research. 34 (1984),879.
3.    

orl-rbt LD50:742 mg/kg

     ARZNAD    Arzneimittel-Forschung. Drug Research. 31 (1981),882.

Safety Profile

Moderately toxic by ingestion and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of F− and NOx.

Specification

 Tormosyl (CAS NO.40507-23-1) is also called 1-Isopropyl-7-methyl-4-(p-fluorophenyl)-2(1H)-quinazolinone ; 4-(4-Fluorophenyl)-7-methyl-1-(1-methylethyl)-2(1H)-quinazolinone ; 4-(p-Fluorophenyl)-1-isopropyl-7-methyl-2(1H)-quinazolinone ; 4-Fluorphenyl-1-isopropyl-7-methyl-2(1H)-chinazolinon ; 4-Fluorphenyl-1-isopropyl-7-methyl-2(1H)-chinazolinon [German] ; 5-24-04-00375 (Beilstein Handbook Reference) ; BRN 0891838 ; Fluproquazona ; Fluproquazona [INN-Spanish] ; Fluproquazone ; Fluproquazonum ; Fluproquazonum [INN-Latin] ; RF 46-790 ; SaH 46-790 . Tormosyl (CAS NO.40507-23-1) is a quinazolinone derivative with potent analgesic and antipyretic effects and also anti-inflammatory action. It has been shown to be effective in a variety of animal species after both oral and parenteral administration, and has a duration of action of several hours. The compound is many times more potent than acetylsalicylic acid and clinically generally resembles ibuprofen and indoprofen in its pharmacological effects, but with significantly less ulcerogenic activity.