- Trandolapril
- Trandolaprilat
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Cas Database |
| Name |
Trandolapril |
EINECS | 618-046-0 |
| CAS No. | 87679-37-6 | Density | 1.181 g/cm3 |
| PSA | 95.94000 | LogP | 3.10210 |
| Solubility | Insoluble in water | Melting Point |
122-123 °C |
| Formula | C24H34N2O5 | Boiling Point | 626 °C at 760 mmHg |
| Molecular Weight | 430.544 | Flash Point | 332.4 °C |
| Transport Information | N/A | Appearance | white powder |
| Safety | Risk Codes | N/A | |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
1H-Indole-2-carboxylicacid, 1-[2-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydro-,[2S-[1[R*(R*)],2a,3aa,7ab]]-;Gopten;Mavik;Odrik;RU 44570; |
Article Data | 11 |
Trandolapril Chemical Properties
Molecular Formula: C24H34N2O5
Molecular Weight: 430.54 g/mol
Protein binding: Trandolapril 80%,(independent of concentration);Trandolaprilat 65 to 94%,(concentration-dependent)
Half life: 6 hours (trandolapril),10 hours (trandolaprilat)
Metabolism: Hepatic
Storage temp.: Room temp
Excretion: Fecal and renal
Index of Refraction: 1.549
Surface Tension: 48.7 dyne/cm
Density: 1.181 g/cm3
Flash Point: 332.4 °C
Appearance: White powder
Solubility in water: Insoluble
Enthalpy of Vaporization: 97.42 kJ/mol
Boiling Point: 626 °C at 760 mmHg
Vapour Pressure of Trandolapril (CAS NO.87679-37-6): 1.55E-16 mmHg at 25 °C
Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals
Following is the structure of Trandolapril (CAS NO.87679-37-6):
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Trandolapril Uses
Trandolapril (CAS NO.87679-37-6) is used to treat high blood pressure, and it can also be used to treat other conditions. Trandolapril is a prodrug deesterified to trandolaprilat. It is believed that it exerts its antihypertensive effect through the renin-angiotensin-aldosterone system.
Trandolapril Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD50 | oral | 2gm/kg (2000mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 27, Pg. 195, 1996. | |
| mouse | LD50 | intraperitoneal | 1285mg/kg (1285mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 27, Pg. 195, 1996. | |
| mouse | LD50 | intravenous | 3gm/kg (3000mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 27, Pg. 195, 1996. | |
| mouse | LD50 | oral | 3990mg/kg (3990mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 27, Pg. 195, 1996. | |
| rat | LD50 | intraperitoneal | 1420mg/kg (1420mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 27, Pg. 195, 1996. | |
| rat | LD50 | intravenous | > 2gm/kg (2000mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 27, Pg. 195, 1996. | |
| rat | LD50 | oral | > 5gm/kg (5000mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 27, Pg. 195, 1996. |
Trandolapril Consensus Reports
Trandolapril (CAS NO.87679-37-6) acts by competitive inhibition of Angiotensin Converting Enzyme (ACE), a key enzyme in the renin-angiotensin system (RAS pathway) ,it plays a very important role in regulating blood pressure.
Trandolapril Safety Profile
RTECS: NL6015178
Some side effects are reported for Trandolapril (CAS NO.87679-37-6) include nausea, vomiting, or diarrhea; headache; dry cough; dizziness or lightheadedness when sitting up or standing; hypotension or fatigue.
Trandolapril Specification
Trandolapril with a CAS number of 87679-37-6, also named (2S,3aR,7aS)-1-[(2S)-2-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid , is an ACE inhibitor. Trandolapril's possible drug interactions: Patients on diuretics maybe will experience an excessive reduction of blood pressure after initiation of therapy with Trandolapril. Trandolapril (CAS NO.87679-37-6) can reduce potassium loss caused by thiazide diuretics, and increase serum potassium when used alone. So hyperkalemia is a possible risk. Increased serum lithum levels can occur in patients who are also on lithium.It should be stored in original container in a cool dark place.
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