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Name |
Triphenylphosphine oxide |
EINECS | 212-338-8 |
CAS No. | 791-28-6 | Density | 1.17g/cm3 |
PSA | 26.88000 | LogP | 3.32600 |
Solubility | slightly soluble in water | Melting Point |
154-158 °C |
Formula | C18H15OP | Boiling Point | 462.9 °C at 760 mmHg |
Molecular Weight | 278.29 | Flash Point | 233.8 °C |
Transport Information | N/A | Appearance | White solid |
Safety | 26-61-36 | Risk Codes | 22-36/37/38-52/53 |
Molecular Structure | Hazard Symbols | Xn, Xi | |
Synonyms |
phosphorane, triphenyl-, oxide;diphenylphosphorylbenzene;TPPO;Triphenyl phosphorus oxide;Phosphine oxide, triphenyl-; |
Article Data | 1217 |
Conditions | Yield |
---|---|
With CuO2H In acetonitrile at 70℃; for 6h; | 100% |
With CuO2H In acetonitrile at 70℃; for 6h; | 100% |
With periodate form of Amberlyst A26 In chloroform at 25℃; for 2h; | 100% |
Conditions | Yield |
---|---|
With pyridine; trifluoroacetic anhydride for 2h; | 100% |
With hexyl sulfide; oxygen In methanol; chloroform for 0.5h; Irradiation; | 100% |
With hexyl sulfide In methanol; chloroform for 1h; Product distribution; Irradiation; other reagents; | 100% |
Conditions | Yield |
---|---|
With oxygen; methylene blue In dichloromethane at -78℃; for 0.0833333h; Irradiation; other reagent; | A 100% B n/a |
With oxygen; methylene blue In dichloromethane Quantum yield; Irradiation; |
Conditions | Yield |
---|---|
With bromonitromethane In benzene | A 100% B 88% |
With bromonitromethane In benzene for 12h; Yield given. Yields of byproduct given; |
Conditions | Yield |
---|---|
With 3-chloro-benzenecarboperoxoic acid In dichloromethane for 20h; Mechanism; other thiophosphoramides are also investigated; | 100% |
With 3,3-dimethyldioxirane In dichloromethane; acetone for 0.0833333h; Ambient temperature; | 100% |
With pyridine; trifluoroacetic anhydride for 3h; | 100% |
[bis(acetoxy)iodo]benzene
triphenylphosphine
benzylamine
A
N-(phenylmethyl)acetamide
B
Triphenylphosphine oxide
Conditions | Yield |
---|---|
Stage #1: [bis(acetoxy)iodo]benzene; triphenylphosphine In chloroform for 1h; Heating; Stage #2: benzylamine In chloroform for 0.166667h; | A 94% B 100% |
3,3-diphenyl-1,2-indanedione
methyl (triphenylphosphoranylidene)acetate
C
Triphenylphosphine oxide
Conditions | Yield |
---|---|
In benzene at 20℃; for 5h; Wittig reaction; | A 70% B 11% C 100% |
3,3-diphenyl-1,2-indanedione
ethyl (triphenylphosphoranylidene)acetate
C
Triphenylphosphine oxide
Conditions | Yield |
---|---|
In benzene at 20℃; for 5h; Wittig reaction; | A 65% B 14% C 100% |
3,3-diphenyl-1,2-indanedione
cyanomethylene triphenylphosphorane
C
Triphenylphosphine oxide
Conditions | Yield |
---|---|
In benzene at 20℃; for 7h; Wittig reaction; | A 63% B 17% C 100% |
(Z)-3-(4-bromophenyl)-3-iodoprop-2-en-1-ol
A
1-bromo-4-((Z)-3-bromo-1-iodopropenyl)benzene
B
Triphenylphosphine oxide
Conditions | Yield |
---|---|
With carbon tetrabromide; triphenylphosphine In dichloromethane at 0 - 20℃; | A 100% B n/a |
IUPAC Name: Diphenylphosphorylbenzene
Synonyms of Triphenyl Phosphine Oxide (CAS NO.791-28-6): 3-Acetylpropionic acid ; 4-Ketovaleric acid ; 4-Oxopentanoic acid ; Acetopropionic acid ; Levulinic acid ; Propionic acid, 3-acetyl- ; gamma-Ketovaleric acid
CAS NO: 791-28-6
Molecular Formula: C18H15OP
Molecular Weight: 791-28-6
Molecular Structure:
EINECS: 212-338-8
H bond acceptors: 1
H bond donors: 0
Freely Rotating Bonds: 3
Polar Surface Area: 26.88 Å2
Index of Refraction: 1.619
Molar Refractivity: 82.91 cm3
Molar Volume: 236.2 cm3
Surface Tension: 48.2 dyne/cm
Density: 1.17 g/cm3
Flash Point: 233.8 °C
Enthalpy of Vaporization: 69.63 kJ/mol
Boiling Point: 462.9 °C at 760 mmHg
Vapour Pressure: 2.62E-08 mmHg at 25°C
Melting point: 154-158 °C
Storage temp: Store at RT
Solubility methanol: 25 mg/mL, clear
Water solubility: slightly soluble
Appearance: White solid
Product Categories of Triphenyl Phosphine Oxide (CAS NO.791-28-6): Catalysis and Inorganic Chemistry;Phosphine Ligands;Phosphorus Compounds
Triphenyl Phosphine Oxide (CAS NO.791-28-6) is used for intermediates in organic synthesis and pharmaceutical, and it is also used for catalysts, extraction agents. Besides, it is still used for fluorescent anti-counterfeit powder.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 450mg/kg (450mg/kg) | National Technical Information Service. Vol. AD607-952, | |
rabbit | LD50 | skin | > 5gm/kg (5000mg/kg) | Food and Cosmetics Toxicology. Vol. 17, Pg. 847, 1979. | |
rat | LD50 | oral | 1850mg/kg (1850mg/kg) | Food and Cosmetics Toxicology. Vol. 17, Pg. 847, 1979. |
Safety Information about Triphenyl Phosphine Oxide (CAS NO.791-28-6):
Hazard Codes: Xn,Xi
Risk Statements: 22-36/37/38-52/53
R22: Harmful if swallowed.
R36/37/38: Irritating to eyes, respiratory system and skin.
R52/53: Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Statements: 26-61-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36: Wear suitable protective clothing.
S61: Avoid release to the environment. Refer to special instructions / safety data sheets.
WGK Germany: 2
RTECS: SZ1676000
HS Code: 29310095
General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam.
Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage: Store in a cool, dry place. Store in a tightly closed container.