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1038924-97-8

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Basic Information
CAS No.: 1038924-97-8
Name: Ethyl (2R,4S)-4-([1,1'-biphenyl]-4-ylmethyl)-2-methyl-4-(2,5-dioxopyrrolidin-1-yl)butanoate
Article Data: 6
Molecular Structure:
Molecular Structure of 1038924-97-8 (Ethyl (2R,4S)-4-([1,1'-biphenyl]-4-ylmethyl)-2-methyl-4-(2,5-dioxopyrrolidin-1-yl)butanoate)
Formula: N/A
Molecular Weight: 393.483
Synonyms: (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-(2,5-dioxopyrrol-1-yl)-2-methyl pentanoate
Density: 1.166±0.06 g/cm3(Predicted)
Boiling Point: 581.3±50.0 °C(Predicted)
Related products
Synthetic route
64-17-5

ethanol

C22H23NO4

1038924-97-8

(2R,4S)-5-biphenyl-4-yl-4-(2,5-dioxopyrrolidin-1-yl)-2-methylpentanoic acid ethyl ester

Conditions
ConditionsYield
With thionyl chloride at 20℃; for 7h;91%
With thionyl chloride at 20℃; for 7h;91%
With thionyl chloride at 50 - 60℃;

(2R,4S)-5-biphenyl-4-yl-4-[3-(2-bromoethoxycarbonyl)propionylamino]-2-methylpentanoic acid

1038924-97-8

(2R,4S)-5-biphenyl-4-yl-4-(2,5-dioxopyrrolidin-1-yl)-2-methylpentanoic acid ethyl ester

Conditions
ConditionsYield
With caesium carbonate In N,N-dimethyl-formamide at 50℃; for 2h;
1012341-50-2

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

1038924-97-8

(2R,4S)-5-biphenyl-4-yl-4-(2,5-dioxopyrrolidin-1-yl)-2-methylpentanoic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: thionyl chloride / 8 h / 0 - 50 °C
2: acetic acid / 12 h / 110 °C
View Scheme
108-30-5

succinic acid anhydride

752174-62-2

(2R,4S)-4-amino-5-biphenyl-4-yl-2-methylpentanoic acid ethyl ester

1038924-97-8

(2R,4S)-5-biphenyl-4-yl-4-(2,5-dioxopyrrolidin-1-yl)-2-methylpentanoic acid ethyl ester

Conditions
ConditionsYield
With acetic acid at 110℃; for 12h; Concentration; Temperature;0.3 g

C18H16O2

1038924-97-8

(2R,4S)-5-biphenyl-4-yl-4-(2,5-dioxopyrrolidin-1-yl)-2-methylpentanoic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: palladium 10% on activated carbon; hydrogen / ethanol / 16 h / 20 °C
2: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Reflux
3: dmap; triethylamine / dichloromethane / 12 h / 20 °C / Cooling with ice
4: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 12 h / 20 °C
5: tetrabutyl ammonium fluoride / tetrahydrofuran / 12 h / 20 °C
6: ruthenium(III) trichloride hydrate; sodium periodate / acetonitrile; tetrachloromethane; water / 5 h / 20 °C / Cooling with ice
7: thionyl chloride / 7 h / 20 °C
View Scheme

C18H18O2

1038924-97-8

(2R,4S)-5-biphenyl-4-yl-4-(2,5-dioxopyrrolidin-1-yl)-2-methylpentanoic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Reflux
2: dmap; triethylamine / dichloromethane / 12 h / 20 °C / Cooling with ice
3: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 12 h / 20 °C
4: tetrabutyl ammonium fluoride / tetrahydrofuran / 12 h / 20 °C
5: ruthenium(III) trichloride hydrate; sodium periodate / acetonitrile; tetrachloromethane; water / 5 h / 20 °C / Cooling with ice
6: thionyl chloride / 7 h / 20 °C
View Scheme

C18H22O2

1038924-97-8

(2R,4S)-5-biphenyl-4-yl-4-(2,5-dioxopyrrolidin-1-yl)-2-methylpentanoic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: dmap; triethylamine / dichloromethane / 12 h / 20 °C / Cooling with ice
2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 12 h / 20 °C
3: tetrabutyl ammonium fluoride / tetrahydrofuran / 12 h / 20 °C
4: ruthenium(III) trichloride hydrate; sodium periodate / acetonitrile; tetrachloromethane; water / 5 h / 20 °C / Cooling with ice
5: thionyl chloride / 7 h / 20 °C
View Scheme

(2R,4R)-1-([1,1'-biphenyl]-4-yl)-5-((tert-butyldimethylsilyl)oxy)-4-methylpentan-2-ol

1038924-97-8

(2R,4S)-5-biphenyl-4-yl-4-(2,5-dioxopyrrolidin-1-yl)-2-methylpentanoic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 12 h / 20 °C
2: tetrabutyl ammonium fluoride / tetrahydrofuran / 12 h / 20 °C
3: ruthenium(III) trichloride hydrate; sodium periodate / acetonitrile; tetrachloromethane; water / 5 h / 20 °C / Cooling with ice
4: thionyl chloride / 7 h / 20 °C
View Scheme

C28H39NO3Si

1038924-97-8

(2R,4S)-5-biphenyl-4-yl-4-(2,5-dioxopyrrolidin-1-yl)-2-methylpentanoic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: tetrabutyl ammonium fluoride / tetrahydrofuran / 12 h / 20 °C
2: ruthenium(III) trichloride hydrate; sodium periodate / acetonitrile; tetrachloromethane; water / 5 h / 20 °C / Cooling with ice
3: thionyl chloride / 7 h / 20 °C
View Scheme

C22H25NO3

1038924-97-8

(2R,4S)-5-biphenyl-4-yl-4-(2,5-dioxopyrrolidin-1-yl)-2-methylpentanoic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: ruthenium(III) trichloride hydrate; sodium periodate / acetonitrile; tetrachloromethane; water / 5 h / 20 °C / Cooling with ice
2: thionyl chloride / 7 h / 20 °C
View Scheme
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