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CAS No.: | 110-52-1 |
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Name: | 1,4-Dibromobutane |
Article Data: | 96 |
Molecular Structure: | |
Formula: | C4H8Br2 |
Molecular Weight: | 215.916 |
Synonyms: | 1,4-Dibrombutan;DBB;1,4 Dibromo Butane;1,4-Butylene Bromide;1,4-Dibromobutane / Tetramethylene Dibromide;1,4-Dibromobutene;Tetramethylene dibromide;Butane, 1,4-dibromo-;Butane,1,4-dibromo-; |
EINECS: | 203-775-5 |
Density: | 1.785 g/cm3 |
Melting Point: | - 20 °C(lit.) |
Boiling Point: | 197 °C at 760 mmHg |
Flash Point: | 65.2 °C |
Solubility: | immiscible with water. |
Appearance: | Clear, colorless liquid |
Hazard Symbols: | T,Xi,C |
Risk Codes: | 25-37/38-41-36/37/38 |
Safety: | 26-39-45-37/39 |
Transport Information: | UN 2810 6.1/PG 3 |
PSA: | 0.00000 |
LogP: | 2.55640 |
Conditions | Yield |
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With 1,2-dibromo-1,1,2,2-tetrachloroethane; triphenylphosphine In dichloromethane at 20℃; for 0.15h; Appel Halogenation; | 95% |
With carbon tetrabromide; triphenylphosphine In chloroform at 20℃; for 240h; | 93% |
With 2,2,2-tribromo-1,3,2-benzodioxaphosphole In chloroform | 86% |
Conditions | Yield |
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With water; boron tribromide In dichloromethane at 23℃; for 23h; regioselective reaction; | 87% |
With hydrogen bromide at 170℃; im Rohr; |
Conditions | Yield |
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With hydrogen bromide; phosphorus tribromide at 80℃; for 0.666667h; | A 85% B 4% |
With hydrogen bromide; phosphorus tribromide at 80℃; for 0.666667h; | A 27% B 53% |
Conditions | Yield |
---|---|
With sulfuric acid; sodium bromide In water for 3h; Heating; | 84.8% |
With hydrogen bromide at 130℃; | |
With sulfuric acid; hydrogen bromide |
Conditions | Yield |
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A n/a B 82% |
1,4-bis-isopentyloxy-butane
A
1,4-dibromo-butane
B
1-bromo-4-isopentyloxy-butane
Conditions | Yield |
---|---|
With hydrogen bromide |
Conditions | Yield |
---|---|
With hydrogen bromide |
Conditions | Yield |
---|---|
With hydrogen bromide |
Conditions | Yield |
---|---|
With hydrogen bromide | |
With hydrogen bromide at 130 - 140℃; im Rohr; |
uvariadiamide
1,4-dibromo-butane
Conditions | Yield |
---|---|
With phosphorus pentabromide | |
With bromine; phosphorus trichloride | |
With phosphorus pentabromide im Vakuum; |
1. Introduction of 1,4-Dibromobutane
1,4-Dibromobutane is a kind of Pharmaceutical intermediates, it is also called Dibromobutane; tetramethylene bromide; Tetramethylene dibromide.
2. Properties of 1,4-Dibromobutane
Melting Point: - 20 °C(lit.)
Boiling Point: 197 °C at 760 mmHg
Flash Point: 65.2 °C
Solubility: immiscible with water.
Appearance: Clear, colorless liquid
3. Toxicity of 1,4-Dibromobutane
1. | mmo-sat 10 µmol/plate | MUREAV Mutation Research. 141 (1984),11. | ||
2. | ipr-mus LD50:300 mg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 14 (1964),668. |