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CAS No.: | 112344-52-2 |
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Name: | flobufen |
Article Data: | 2 |
Molecular Structure: | |
Formula: | C17H14 F2 O3 |
Molecular Weight: | 304.293 |
Synonyms: | 4-(2',4'-Difluorobiphenyl-4-yl)-4-oxo-2-methylbutanoicacid; Flobufen; VUFB 16066 |
Density: | 1.272g/cm3 |
Boiling Point: | 456.5°Cat760mmHg |
Flash Point: | 229.9°C |
PSA: | 54.37000 |
LogP: | 3.92530 |
4-(2',4'-difluorobiphenyl-4-yl)-2-methylene-4-oxobutanoic acid
4-(2',4'-difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoic acid
Conditions | Yield |
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With hydrogen; palladium on activated charcoal In 1,4-dioxane at 20℃; under 3750.3 Torr; | 74% |
2,4-difluorobiphenyl
2-methylsuccinic anhydride
B
4-(2',4'-difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoic acid
Conditions | Yield |
---|---|
With aluminium trichloride In 1,2-dichloro-ethane 1) 10 degC, 4 h, 2) 20 degC, 16 h; | A n/a B 40.2% |
2-methylenesuccinic acid
4-(2',4'-difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoic acid
Conditions | Yield |
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Multi-step reaction with 3 steps 1: 92 percent / Ac2O / 4 h / 80 °C 2: 63 percent / AlCl3 / CH2Cl2 / 1.) 10 deg C, 4 h, 2.) 20 deg C, 2 h 3: 74 percent / H2 / Pd/C / dioxane / 20 °C / 3750.3 Torr View Scheme |
itaconic acid anhydride
4-(2',4'-difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 63 percent / AlCl3 / CH2Cl2 / 1.) 10 deg C, 4 h, 2.) 20 deg C, 2 h 2: 74 percent / H2 / Pd/C / dioxane / 20 °C / 3750.3 Torr View Scheme |
(R)-1-phenyl-ethyl-amine
4-(2',4'-difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoic acid
Conditions | Yield |
---|---|
In diethyl ether; acetone for 1h; | 97% |
L-lysine
4-(2',4'-difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoic acid
Conditions | Yield |
---|---|
In water; dimethyl sulfoxide | 95% |
2-methyl-propan-1-ol
4-(2',4'-difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoic acid
Conditions | Yield |
---|---|
With thionyl chloride 1.) -15 deg C, 30 min, 2.) 40-45 deg C, 2 h; | 91% |
4-(2',4'-difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoic acid
4-(2',4'-difluorobipenyl-4-yl)-2-methylbutyric acid
Conditions | Yield |
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With hydrogen; palladium on activated charcoal In water; acetic acid at 60℃; for 5h; | 87% |
4-(2',4'-difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoic acid
cyclohexylamine
Conditions | Yield |
---|---|
In diethyl ether; acetone for 1h; | 86% |
4-(2',4'-difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoic acid
benzylamine
Conditions | Yield |
---|---|
In water; dimethyl sulfoxide | 72% |