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| CAS No.: | 114676-61-8 |
|---|---|
| Name: | (2S,4R)-4-hydroxy-2-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester |
| Article Data: | 5 |
| Molecular Structure: | |
|
|
|
| Formula: | C10H19NO3 |
| Molecular Weight: | 201.266 |
| Density: | 1.094±0.06 g/cm3(Predicted) |
| Melting Point: | 75-78 °C |
| Boiling Point: | 282.5±33.0 °C(Predicted) |
| PSA: | 49.77000 |
| LogP: | 1.31450 |
- 144851-82-1METHYL2-AMINO-3-FLUOROBENZOATE
- 483366-12-7(2S,4R)-1-Boc-2-cyano-4-hydroxypyrrolidine
- 173606-50-3BOC-10-AMINODECANOIC ACID
- 361456-36-2METHYL (R)-(+)-ISOCYANATO-3-PHENYLPROPI&
- 5156-58-1N-(1-Benzyl-4-pipperidinyl)-N-phenylpropanamide HCl
- 81281-59-67-Benzylideneaminotheophylline
- 50288-62-5threo-Phenyl-2-piperidyl acetamide
- 82993-81-5D-threo-Ritalinic acid hydrochloride
- 47087-37-6Z-D-Glu-OMe
- 1219080-61-1IMIDAZOLE-2-BORONIC ACID
- 213699-41-3
tert-butyl (2S,4R)-4-((tert-butyldimethylsilyl)oxy)-2-methylpyrrolidine-1-carboxylate
- 114676-61-8
tert-butyl (2S,4R)-4-hydroxyl-2-methylpyrrolidine-1-carboxylate
| Conditions | Yield |
|---|---|
| With tetrabutyl ammonium fluoride In tetrahydrofuran at 20℃; | 99% |
| With tetrabutyl ammonium fluoride In tetrahydrofuran for 2.5h; Yield given; | |
| With tetrabutyl ammonium fluoride In tetrahydrofuran |
- 109431-87-0
(R)-tert-butyl 3-hydroxypyrrolidine-1-carboxylate
- 77-78-1
dimethyl sulfate
A
- 114676-93-6
(2R,4R)-tert-butyl 4-hydroxy-2-methylpyrrolidine-1-carboxylate
B
- 114676-61-8
tert-butyl (2S,4R)-4-hydroxyl-2-methylpyrrolidine-1-carboxylate
| Conditions | Yield |
|---|---|
| With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium In tetrahydrofuran 1.) -78 to -46 deg C, 2 h, 2.) -78 deg C; Yield given. Yields of byproduct given. Title compound not separated from byproducts; | |
| With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium In tetrahydrofuran 1.) -78 to -46 deg C, 2 h, 2.) -78 deg C; Yield given. Yields of byproduct given; |
- 24424-99-5
di-tert-butyl dicarbonate
- 114676-61-8
tert-butyl (2S,4R)-4-hydroxyl-2-methylpyrrolidine-1-carboxylate
| Conditions | Yield |
|---|---|
| Multi-step reaction with 6 steps 1: 90 percent / triethylamine / CH2Cl2 / 12 h 2: 99 percent / imidazole / dimethylformamide / 1.5 h / Ambient temperature 3: 93 percent / lithium borohydride / tetrahydrofuran / 16 h 4: 94 percent / triethylamine / CH2Cl2 / 15 h 5: lithium triethylborohydride / tetrahydrofuran / 2 h 6: tetra-n-butylammonium fluoride / tetrahydrofuran / 2.5 h View Scheme |
- 114676-69-6
(2R,4R)-1-tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate
- 114676-61-8
tert-butyl (2S,4R)-4-hydroxyl-2-methylpyrrolidine-1-carboxylate
| Conditions | Yield |
|---|---|
| Multi-step reaction with 5 steps 1: 99 percent / imidazole / dimethylformamide / 1.5 h / Ambient temperature 2: 93 percent / lithium borohydride / tetrahydrofuran / 16 h 3: 94 percent / triethylamine / CH2Cl2 / 15 h 4: lithium triethylborohydride / tetrahydrofuran / 2 h 5: tetra-n-butylammonium fluoride / tetrahydrofuran / 2.5 h View Scheme |
- 114676-59-4
(2R,4R)-4-hydroxy-2-methoxycarbonylpyrrolidine hydrochloride
- 114676-61-8
tert-butyl (2S,4R)-4-hydroxyl-2-methylpyrrolidine-1-carboxylate
| Conditions | Yield |
|---|---|
| Multi-step reaction with 6 steps 1: 90 percent / triethylamine / CH2Cl2 / 12 h 2: 99 percent / imidazole / dimethylformamide / 1.5 h / Ambient temperature 3: 93 percent / lithium borohydride / tetrahydrofuran / 16 h 4: 94 percent / triethylamine / CH2Cl2 / 15 h 5: lithium triethylborohydride / tetrahydrofuran / 2 h 6: tetra-n-butylammonium fluoride / tetrahydrofuran / 2.5 h View Scheme |
- 114676-58-3
(2R,4R)-tert-butyl 4-((tert-butyldimethylsilyl)oxy)-2-(hydroxymethyl)pyrrolidine-1-carboxylate
- 114676-61-8
tert-butyl (2S,4R)-4-hydroxyl-2-methylpyrrolidine-1-carboxylate
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: 94 percent / triethylamine / CH2Cl2 / 15 h 2: lithium triethylborohydride / tetrahydrofuran / 2 h 3: tetra-n-butylammonium fluoride / tetrahydrofuran / 2.5 h View Scheme | |
| Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 0 °C 2: sodium triethylborohydride / tetrahydrofuran / 2 h / 5 - 20 °C 3: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C View Scheme |
- 114676-61-8
tert-butyl (2S,4R)-4-hydroxyl-2-methylpyrrolidine-1-carboxylate
| Conditions | Yield |
|---|---|
| Stage #1: tert-butyl (2S,4R)-4-hydroxyl-2-methylpyrrolidine-1-carboxylate With sodium hydride In tetrahydrofuran; mineral oil at 10 - 41℃; for 0.416667h; Stage #2: 1-(2-chloro-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl)ethan-1-one In tetrahydrofuran; mineral oil at 40℃; Temperature; | 99% |
- 104-15-4
toluene-4-sulfonic acid
- 114676-61-8
tert-butyl (2S,4R)-4-hydroxyl-2-methylpyrrolidine-1-carboxylate
| Conditions | Yield |
|---|---|
| In water; isopropyl alcohol at 62℃; | 93% |
- 114676-61-8
tert-butyl (2S,4R)-4-hydroxyl-2-methylpyrrolidine-1-carboxylate
- 74-88-4
methyl iodide
| Conditions | Yield |
|---|---|
| With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 1h; | 92% |
- 766-11-0
5-bromo-2-fluoropyridine
- 114676-61-8
tert-butyl (2S,4R)-4-hydroxyl-2-methylpyrrolidine-1-carboxylate
| Conditions | Yield |
|---|---|
| With sodium hydride In tetrahydrofuran at 90℃; for 2h; | 86% |
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