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CAS No.: | 130642-50-1 |
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Name: | Loratadine ketone |
Article Data: | 2 |
Molecular Structure: | |
Formula: | C20H23 Cl N2 O |
Molecular Weight: | 342.868 |
Synonyms: | (1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]-2-pyridinyl]methanone |
Density: | 1.169±0.06 g/cm3(Predicted) |
Melting Point: | 179-186 ºC |
Boiling Point: | 462.0±45.0 °C(Predicted) |
PSA: | 33.20000 |
LogP: | 3.98260 |
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
(1-methyl-4-piperidyl)magnesium chloride
{3-[2-(3-Chloro-phenyl)-ethyl]-pyridin-2-yl}-(1-methyl-piperidin-4-yl)-methanone
Conditions | Yield |
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With hydrogenchloride 1.) THF, reflux; Multistep reaction; | |
In pyridine |
N-tert-butyl-3-methylpyridine-2-carboxamide
{3-[2-(3-Chloro-phenyl)-ethyl]-pyridin-2-yl}-(1-methyl-piperidin-4-yl)-methanone
Conditions | Yield |
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Multi-step reaction with 3 steps 1: 1.) n-BuLi / 1.) THF, -40 deg C 2: POCl3 / Heating 3: 2.) aq. HCl / 1.) THF, reflux View Scheme |
3-<2-(3-chlorophenyl)ethyl>-N-(1,1-dimethylethyl)-2-pyridinecarboxamide
{3-[2-(3-Chloro-phenyl)-ethyl]-pyridin-2-yl}-(1-methyl-piperidin-4-yl)-methanone
Conditions | Yield |
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Multi-step reaction with 2 steps 1: POCl3 / Heating 2: 2.) aq. HCl / 1.) THF, reflux View Scheme |
1-Chloro-3-chloromethyl-benzene
{3-[2-(3-Chloro-phenyl)-ethyl]-pyridin-2-yl}-(1-methyl-piperidin-4-yl)-methanone
Conditions | Yield |
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Multi-step reaction with 3 steps 1: 1.) n-BuLi / 1.) THF, -40 deg C 2: POCl3 / Heating 3: 2.) aq. HCl / 1.) THF, reflux View Scheme |
{3-[2-(3-Chloro-phenyl)-ethyl]-pyridin-2-yl}-(1-methyl-piperidin-4-yl)-methanone
{3-[2-(3-chloro-phenyl)-ethyl]-pyridin-2-yl}-(1-methyl-piperidin-4-yl)-methanol
Conditions | Yield |
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With sodium tetrahydroborate In ethanol for 3h; | 99% |
{3-[2-(3-Chloro-phenyl)-ethyl]-pyridin-2-yl}-(1-methyl-piperidin-4-yl)-methanone
N-methyldesloratadine
Conditions | Yield |
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With trifluorormethanesulfonic acid Heating; |
{3-[2-(3-Chloro-phenyl)-ethyl]-pyridin-2-yl}-(1-methyl-piperidin-4-yl)-methanone
10-chloro-11-(1-methyl-piperidin-4-yl)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
Conditions | Yield |
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Multi-step reaction with 2 steps 1: 99 percent / naBH4 / ethanol / 3 h 2: 3 percent / PPA / 3 h / 170 - 175 °C View Scheme |
{3-[2-(3-Chloro-phenyl)-ethyl]-pyridin-2-yl}-(1-methyl-piperidin-4-yl)-methanone
8-chloro-11-(1-methyl-piperidin-4-yl)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
Conditions | Yield |
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Multi-step reaction with 2 steps 1: 99 percent / naBH4 / ethanol / 3 h 2: 5 percent / PPA / 3 h / 170 - 175 °C View Scheme |
{3-[2-(3-Chloro-phenyl)-ethyl]-pyridin-2-yl}-(1-methyl-piperidin-4-yl)-methanone
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 99 percent / naBH4 / ethanol / 3 h 2: 3 percent / PPA / 3 h / 170 - 175 °C 3: NEt3 / benzene / 1.5 h / Heating 4: 1.) Zn dust, AcOH / 1.) 80-100 deg C, 1 h, 2.) CH2Cl2, reflux, 1 h View Scheme |
{3-[2-(3-Chloro-phenyl)-ethyl]-pyridin-2-yl}-(1-methyl-piperidin-4-yl)-methanone
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 99 percent / naBH4 / ethanol / 3 h 2: 5 percent / PPA / 3 h / 170 - 175 °C 3: NEt3 / benzene / 1.5 h / Heating 4: 1.) Zn dust, AcOH / 1.) 80-100 deg C, 1 h, 2.) CH2Cl2, reflux, 1 h View Scheme |