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CAS No.: | 14340-01-3 |
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Name: | Gestadienol |
Article Data: | 7 |
Molecular Structure: | |
Formula: | C20H26 |
Molecular Weight: | 314.425 |
Synonyms: | Gestadienol;19-Norpregna-4,9-diene-3,20-dione, 17-hydroxy-; |
Density: | 1.20 |
Melting Point: | 203-205℃ |
Boiling Point: | 515.5±50.0 °C(Predicted) |
PSA: | 54.37000 |
LogP: | 3.51250 |
17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione
Conditions | Yield |
---|---|
With water; trifluoroacetic acid In tetrahydrofuran at 20℃; for 2h; | 77% |
Conditions | Yield |
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Stage #1: C25H35NO4; methyllithium In diethyl ether at 0 - 10℃; for 4h; Cooling with ice; Stage #2: With hydrogenchloride; water In acetone at 25℃; for 8h; Solvent; | 72% |
methyllithium
17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione
Conditions | Yield |
---|---|
Stage #1: 17α-[(±)1-(1-ethoxyl)ethyl]oxyl-17β-cyano-3,3-(ethylene-dioxy)-19-norpregna-5(10),9(11)-diene; methyllithium In diethyl ether at 0 - 10℃; for 4h; Stage #2: With hydrogenchloride In acetone at 25℃; for 8h; | 72% |
3,3-ethylenedioxy-17β-cyano-17α-chloromethyl(dimethyl)siloxy estren-5(10),9(11)diene
B
17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione
Conditions | Yield |
---|---|
With di-t-butyl biphenyl; lithium In tetrahydrofuran at -70℃; for 2.25h; Title compound not separated from byproducts; |
17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 98 percent / DMAP; TEA / tetrahydrofuran / 20 °C 2: Li; di-t-butyl biphenyl / tetrahydrofuran / 2.25 h / -70 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: toluene-4-sulfonic acid / dichloromethane / 4 h / 20 °C / Cooling with ice; Large scale 2.1: diethyl ether / 4 h / 0 - 10 °C / Cooling with ice 2.2: 8 h / 25 °C View Scheme |
17α-hydroxy-19-norpregna-5(10),9(11)-diene-3,20-dione 3,20-bis(ethylene acetal)
17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione
ethylene deltenone
B
17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: acetic acid / methanol / 20 °C / Large scale 2.1: ethyl vinyl ether; toluene-4-sulfonic acid / tetrahydrofuran / 3 h / 20 °C / Cooling with ice; Large scale 2.2: 8 h / 0 - 10 °C / Large scale 2.3: 4 h / 25 °C / Large scale View Scheme | |
Multi-step reaction with 3 steps 1.1: acetic acid / methanol / 20 °C / Large scale 2.1: toluene-4-sulfonic acid / dichloromethane / 4 h / 20 °C / Cooling with ice; Large scale 3.1: 2 h / 0 - 10 °C / Cooling with ice 3.2: 0.5 h View Scheme | |
Multi-step reaction with 3 steps 1.1: acetic acid / methanol / 20 °C / Large scale 2.1: toluene-4-sulfonic acid / dichloromethane / 4 h / 20 °C / Cooling with ice; Large scale 3.1: tetrahydrofuran; 2-methyltetrahydrofuran / 4 h / 0 - 10 °C / Cooling with ice 3.2: 2 h / 25 °C View Scheme | |
Multi-step reaction with 3 steps 1: acetic acid / methanol / 20 °C 2: toluene-4-sulfonic acid / tetrahydrofuran / 3 h / 20 °C / Cooling; Large scale 3: tetrahydrofuran; diethyl ether / 8 h / 0 - 20 °C / Cooling; Large scale View Scheme |
ethylene deltenone
17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: acetic acid / methanol / 20 °C / Large scale 2.1: toluene-4-sulfonic acid / dichloromethane / 4 h / 20 °C / Cooling with ice; Large scale 3.1: diethyl ether / 4 h / 0 - 10 °C / Cooling with ice 3.2: 8 h / 25 °C View Scheme |
methyllithium
B
17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione
Conditions | Yield |
---|---|
Stage #1: C25H35NO4; methyllithium In tetrahydrofuran; 2-methyltetrahydrofuran at 0 - 10℃; for 4h; Cooling with ice; Stage #2: With hydrogenchloride; water In methanol at 25℃; for 2h; Solvent; Overall yield = 73%; Overall yield = 6.6 g; | |
In tetrahydrofuran; diethyl ether at 0 - 20℃; for 8h; Cooling; Large scale; Overall yield = 1036 g; |
B
17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione
Conditions | Yield |
---|---|
Stage #1: C25H35NO4; methyl Grignard reagent at 0 - 10℃; for 2h; Cooling with ice; Stage #2: With hydrogenchloride; water for 0.5h; Solvent; Overall yield = 68%; Overall yield = 2.1g; |
Gestadene is one kind of powder. Gestation is the carrying of an embryo or fetus inside a female viviparous animal. Mammals during pregnancy can have one or more gestations at the same time (multiple gestations). The Product Categories of this chemical is API.