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162118-01-6

Basic Information
CAS No.: 162118-01-6
Name: (S)-DIPHENYLALANINOL
Article Data: 4
Molecular Structure:
Molecular Structure of 162118-01-6 ((S)-DIPHENYLALANINOL)
Formula: C15H17 N O
Molecular Weight: 227.306
Synonyms: Benzenepropanol,b-amino-g-phenyl-, (S)- (9CI)
Density: 1.113±0.06 g/cm3(Predicted)
Boiling Point: 410.0±40.0 °C(Predicted)
PSA: 46.25000
LogP: 2.83840
Synthetic route
155836-47-8

tert-butyl N-[(1S)-1-(hydroxymethyl)-2,2-diphenylethyl]carbamate

162118-01-6

(S)-2-amino-3,3-diphenyl-1-propanol

Conditions
ConditionsYield
With hydrogenchloride In tetrahydrofuran at 20℃; for 48h; Hydrolysis;100%
With trifluoroacetic acid for 1h; Cooling with ice;

C25H22N4O3

162118-01-6

(S)-2-amino-3,3-diphenyl-1-propanol

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran at 60℃;
25699-85-8

3-(1-imidazolyl)benzonitrile

162118-01-6

(S)-2-amino-3,3-diphenyl-1-propanol

C25H21N3O

Conditions
ConditionsYield
With zinc(II) trifluoroacetate In chlorobenzene at 130℃; for 48h; Inert atmosphere; Schlenk technique;93%
10344-69-1

diethyl malonoimidate dihydrochloride

162118-01-6

(S)-2-amino-3,3-diphenyl-1-propanol

bis((S)-4-benzhydryl-4,5-dihydrooxazol-2-yl)methane

Conditions
ConditionsYield
In dichloromethane at 40℃; for 8h;75%
1436-43-7

quinoline-2-carbonitrile

162118-01-6

(S)-2-amino-3,3-diphenyl-1-propanol

(S)-4-benzhydryl-2-(quinolin-2-yl)-4,5-dihydrooxazole

Conditions
ConditionsYield
Stage #1: quinoline-2-carbonitrile With sodium methylate In methanol at 20℃;
Stage #2: (S)-2-amino-3,3-diphenyl-1-propanol With toluene-4-sulfonic acid In toluene at 80℃;
64%
1246616-94-3

ethyl 5-(benzyloxy)-6-((2-methoxyethyl)carbamoyl)-4-oxo-4H-pyran-3-carboxylate

162118-01-6

(S)-2-amino-3,3-diphenyl-1-propanol

1370248-11-5

ethyl (S)-5-(benzyloxy)-1-(3-hydroxy-1,1-diphenylpropan-2-yl)-6-((2-methoxyethyl)carbamoyl)-4-oxo-1,4-dihydropyridine-3-carboxylate

Conditions
ConditionsYield
In 5,5-dimethyl-1,3-cyclohexadiene at 120℃; for 0.5h;52%
With triethylamine In toluene at 90℃; for 1h;9.12 g
2893-33-6

pyridine-2,6-dinitrile

162118-01-6

(S)-2-amino-3,3-diphenyl-1-propanol

2,6-bis((S)-4-benzhydryl-4,5-dihydrooxazol-2-yl)pyridine

Conditions
ConditionsYield
With zinc trifluoromethanesulfonate In toluene for 48h; Reflux;35%
24424-99-5

di-tert-butyl dicarbonate

162118-01-6

(S)-2-amino-3,3-diphenyl-1-propanol

155836-47-8

tert-butyl N-[(1S)-1-(hydroxymethyl)-2,2-diphenylethyl]carbamate

Conditions
ConditionsYield
In dichloromethane
2766-74-7

5-chlorothien-2-ylsulfonyl chloride

162118-01-6

(S)-2-amino-3,3-diphenyl-1-propanol

1132652-97-1

C19H18ClNO3S2

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran
32621-46-8

diphenylamine-2,2'-dicarbonyl chloride

162118-01-6

(S)-2-amino-3,3-diphenyl-1-propanol

C44H41N3O4

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃;
Raw Materials
155836-47-8
Downstream Products
155836-47-8
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